On February 10, 2026 Protai, www.protai.bio, an AI drug discovery startup, reported its participation in a series of major scientific conferences this spring, where it will present significant advances in its AIMS proteomics-aware-AI drug discovery platform and breakthrough preclinical results of its best-in-class KAT6A degrader program.

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Protai’s upcoming spring 2026 conference presentations:
HDX-MS conference Strasbourg, 9-13 March 2026, Dr. Anjana Shenoy, Head of Proteomics
ACS2026, Atlanta, March 2026, Kirill Pevzner, CTO
TPD summit Europe, London, March 2026, Eran Seger (CEO) & Kirill Pevzner (CTO)
Drug discovery chemistry, San Diego, April 2026, Kirill Pevzner (CTO)
AACR 2026, San Diego, April 2026, Eran Seger (CEO) & Kirill Pevzner (CTO)
Protai’s presentations will highlight the following key achievements:

AIMS Platform validated: Integration of AI-driven structural modeling with mass-spectrometry-based structural proteomics, which supported the lead optimization of the KAT6A Targeted Protein Degradation program.
PRT-001 best-in-class results: New in vivo results from the company’s KAT6A degrader program.
"By combining proteomics-driven experimental evidence with next-generation AI modeling, we are revealing opportunities that were previously invisible to classical drug discovery methods." Said Eran Seger, Protai’s CEO. "These upcoming presentations will showcase the power of combining experimental data and AI, and its outcome in rapidly generating highly effective drugs for huge clinical unmet needs. "

(Press release, Protai Bio, FEB 10, 2026, View Source [SID1234662580])

On February 10, 2026 Nektar Therapeutics (Nasdaq: NKTR), a clinical-stage biotechnology company focused on the development of innovative medicines in the field of immunotherapy, reported that it has commenced an underwritten public offering of $300,000,000 of its shares of its common stock and, in lieu of common stock to certain investors, pre-funded warrants to purchase shares of its common stock. All of the shares of common stock and pre-funded warrants to be sold in this offering are being offered by Nektar. In addition, Nektar intends to grant the underwriters a 30-day option to purchase up to an additional $45,000,000 of shares of its common stock at the public offering price per share, less underwriting discounts and commissions. The proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Nektar intends to use the net proceeds from the offering for general corporate purposes, which may include research and development, clinical development (including Phase 3 trials for rezpegaldesleukin) and manufacturing costs to support the advancement of its drug candidates, as well as other general corporate purposes.

Jefferies, TD Cowen, and Piper Sandler are acting as joint bookrunning managers for the offering.

The securities described above are being offered pursuant to a shelf registration statement on Form S-3ASR (No. 333-291466) that was filed with the U.S. Securities and Exchange Commission (the "SEC") on November 12, 2025 and automatically became effective upon filing. This offering is being made only by means of a prospectus supplement and an accompanying prospectus that form a part of the registration statement.

A preliminary prospectus supplement related to and describing the terms of the offering will be filed with the SEC and will be available on the SEC’s website located at www.sec.gov. Copies of the preliminary prospectus supplement and an accompanying prospectus related to the offering may also be obtained, when available, from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, New York, NY 10022, by telephone at (877) 821-7388, or by email at [email protected]; TD Securities (USA) LLC, c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717 or by email at [email protected]; or Piper Sandler & Co., 350 North 5th Street, Suite 1000, Minneapolis, MN 55401, Attention: Prospectus Department, by telephone at (800) 747-3924, or by email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of that state or jurisdiction.

(Press release, Nektar Therapeutics, FEB 10, 2026, View Source [SID1234662579])

On February 10, 2026 Ferronova reported it has completed enrolment of patients for its two-year trial to progress commercialisation of FerroTrace, a novel nanoparticle image-guided surgery solution for hard-to-treat cancers.

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The technology is intended to assist surgeons in identifying lymph nodes involved in metastatic spread, thereby enabling targeted removal and reducing the risk of post-surgical recurrence. The study is the first of its kind in which tracer injection to map lymphatic drainage pathways is performed prior to any chemotherapy or radiotherapy.

Key highlights

Patient enrolment has been completed in adults with gastric and oesophageal cancers across five hospital sites in Australia, with a total of 62 patients enrolled, exceeding initial projections.
Evaluations and results from the trial are expected to be available in July 2026.
The trial follows several smaller first-in-human studies conducted between 2020-2024.
FerroTrace addresses an unmet need in surgical guidance for hard-to-treat cancers, with oesophageal and stomach cancers in the world’s top five deadliest cancer types.
Stomach and oesophageal cancers affect more than 1.8 million people worldwide each year, with recurrence after surgery occuring in up to 60% of patients. In Australia, three-year survival for oseophageal cancer remains at just 27%.
FerroTrace uses super-paramagnetic iron oxide nanoparticles that bind to cells within lymph nodes. The technology is designed to support more precise surgery, helping surgeons to identify and remove cancer-affected lymph nodes that are frequently missed during standard procedures.

Stewart Bartlett Chief Executive Officer of Ferronova said he was delighted that the trial had completed recruitment.

"The investigators at the Royal Adelaide, Queen Elizabeth, Flinders, Austin Hospital, and Peter MacCallum Cancer Centre have done an amazing job recruiting patients in a relatively short time. We are looking forward to working with them to complete the final follow-up visits and analyse the data."

"We hope to give surgeons the opportunity to work with greater diagnostic accuracy and precision, enabling less invasive surgery in some patients, and more precise surgery overall, ensuring all cancer-affected lymph nodes are identified and removed. This trial is an important step in validating our technology as we move towards commercial availability."

Appointment of new advisory board member
Ferronova has also appointed a new scientific advisory board member with Ms Aki Smith, a patient advocate, taking up the role this month. Ms Smith founded the US-based charity ‘Hope for Stomach Cancer’ following her father’s diagnosis. The charity provides resources and support to those living with stomach cancer and their families.

Mr Bartlett welcomed Ms Smith to the advisory board, saying her lived experience will help to inform future trial design and innovations.

"The role of Ms Smith and other members for the scientific advisory board is very important to our company. Ferronova is deeply committed to finding new solutions for those affected by these aggressive and difficult to treat cancers.

"We are very supportive of patients having a greater voice in the development and evaluation of new treatments, including those involving our technology."

(Press release, Ferronova, FEB 9, 2026, View Source [SID1234662578])

On February 10, 2026 Lantern Pharma Inc. (NASDAQ: LTRN), a clinical-stage biopharmaceutical company leveraging artificial intelligence to accelerate oncology drug discovery and development, reported that CEO and President Panna Sharma will present at the 7th Glioblastoma Drug Development Summit, February 17–19, 2026, in Boston, MA.

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More information about the summit is available at: https://glioblastoma-drugdevelopment.com.

Lantern’s proprietary AI and machine learning platform, RADR, powered the development of LP-184 / STAR-001, a novel brain-penetrant therapeutic candidate. This work has driven the creation of Lantern’s wholly owned subsidiary, Starlight Therapeutics, which is advancing clinical development for multiple CNS cancers, including recurrent glioblastoma and pediatric brain tumors such as atypical teratoid/rhabdoid tumors (ATRT)—for which STAR-001 has received both FDA Orphan Drug Designation and Rare Pediatric Disease Designation.

In his presentation on Day Two (Thursday, February 19, 2026, at 10:30 a.m. ET), Mr. Sharma will highlight how Lantern applied RADR to:

Elucidate the mechanism of action of STAR-001
Identify patient biomarkers to inform clinical use
Select optimal cancer indications
Discover novel combination therapies in neuro-oncology
The talk will emphasize AI-driven insights and approaches that are helping overcome challenges in treating aggressive brain cancers like glioblastoma and ATRT.

(Press release, Lantern Pharma, FEB 10, 2026, View Source [SID1234662576])

On February 10, 2026 Oncotelic Therapeutics, Inc. (OTCQB: OTLC) ("Oncotelic" or the "Company"), a clinical-stage biopharmaceutical company focused on oncology, immunotherapy, and CNS-related diseases, reported an update on key development progress achieved during 2025 and outlined its strategic direction as the Company enters 2026 with continued momentum across its pipeline.

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2025: Continued Execution Across a Late-Stage, Diversified Pipeline

Oncotelic transitioned from platform build-out to execution and validation, advancing AI-driven discovery (PDAOAI), moving key assets into the clinic, publishing high-impact translational science, and reinforcing asset value through independent validation. Collectively, these milestones establish a strong foundation for late-stage development, partnering, and strategic financing.

Oncotelic Therapeutics – 2025 Key Accomplishments

1. Platform Innovation & AI Enablement (PDAOAI)

In 2025, Oncotelic formally unveiled PDAOAI, its proprietary AI-enabled knowledge platform built on a comprehensive TGF-β-centric corpus. The platform was expanded to support interactive querying, biomarker discovery, and translational hypothesis generation, and was publicly introduced alongside peer-reviewed GBM and pancreatic cancer research. PDAOAI now functions as a cross-program decision-support layer integrating molecular biology, clinical outcomes, and regulatory-grade literature.

2. Clinical Progress & First-in-Human Readiness

Oncotelic achieved multiple clinical milestones across its pipeline. The company successfully completed a Phase 1 clinical trial of OT-101 in combination with IL-2. In parallel, its IV everolimus Deciparticle program (Sapu-003) advanced from preclinical development into first-in-human clinical testing.

3. Deciparticle Platform Validation (Sapu-003)

Throughout 2025, Oncotelic released a coordinated body of data validating the Deciparticle platform:

Demonstrated broad applicability across hydrophobic small-molecule drug classes
Reported favorable PK and tissue-distribution profiles, including reduced gastrointestinal accumulation compared with oral everolimus
Introduced a biomarker-guided framework to identify patient populations most likely to benefit from IV mTOR inhibition
These results position Deciparticle as a differentiated delivery technology for oncology and other systemic indications.

4. Peer-Reviewed Science & Biomarker Leadership

Oncotelic and collaborators published multiple peer-reviewed studies in 2025, reinforcing the company’s leadership in TGFB2-centric biology. Key publications linked TGFB2 expression and methylation status to survival outcomes in pancreatic cancer, glioblastoma, and liver cancer, including age- and context-dependent effects. Additional work reviewed sub-20 nm nanoparticle design principles, supporting the scientific rationale behind the Deciparticle platform.

5. Strategic Partnerships & Global Development Infrastructure

The company entered a strategic partnership with Medicilon to access rapid IND-enabling capabilities. These capabilities complement Oncotelic’s global regulatory strategy.

6. Corporate Development, Valuation & Visibility

In 2025, an independent third-party analysis valued the GMP Bio joint-venture pipeline at approximately $1.7 billion, materially strengthening Oncotelic’s asset-level valuation narrative. The company increased capital-markets visibility through various investor presentations, while continuing disciplined communication around pipeline maturation and platform leverage.

Looking Ahead to 2026: Sustained Momentum, Strategic Execution, and Value Recognition

As the Company enters 2026, Oncotelic plans to build on the progress achieved in 2025 with an emphasis on continued development momentum, thoughtful capital allocation, strategic execution, and increased financial transparency. The Company’s forward priorities include:

Advancing clinical programs toward their next inflection points
Further evaluating regulatory and development pathways across oncology and CNS indications
Exploring partnership, licensing, and collaboration opportunities aligned with its late-stage assets
Continuing to strengthen operational readiness to support future growth initiatives
Completing a second independent U.S.-based valuation to support the remeasurement of its 45% equity interest in the GMP Bio joint venture, with the resulting valuation expected to be reflected on the Company’s balance sheet upon completion, subject to applicable accounting standards

Oncotelic believes its steady progress in 2025 has positioned the Company with a clear development trajectory, enhanced asset visibility, and multiple opportunities to unlock long-term value.

(Press release, Oncotelic, FEB 10, 2026, View Source [SID1234662575])