On May 13, 2025 GSK plc (LSE/NYSE: GSK), with its development partner iTeos Therapeutics, Inc., has reported that it is ending the development programme for belrestotug, an anti-TIGIT monoclonal antibody (Press release, GlaxoSmithKline, MAY 13, 2025, View Source [SID1234652901]). The decision is based on new interim analyses from the phase 2 GALAXIES Lung-201 and GALAXIES H&N-202 studies, which did not meet the established efficacy criteria for continued development. As a result, the collaboration and all belrestotug-containing study cohorts are ending.

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GSK in Oncology
Our ambition in oncology is to help increase overall quality of life, maximise survival and change the course of disease, expanding from our current focus on blood and women’s cancers into lung and gastrointestinal cancers, as well as other solid tumours. This includes accelerating priority programmes such as antibody-drug conjugates targeting B7-H3 and B7-H4, and IDRX-42, a highly selective KIT tyrosine kinase inhibitor.