On June 18, 2025 Oxford Vacmedix (OVM) reported that patient recruitment in the ongoing Phase 1 trial of OVM-200 has been completed (Press release, Oxford Vacmedix, JUN 18, 2025, https://oxfordvacmedix.com/patient-recruitment-completed-in-ovm-200-phase-1-trial/?utm_source=rss&utm_medium=rss&utm_campaign=patient-recruitment-completed-in-ovm-200-phase-1-trial [SID1234653979]). 24 patients have been recruited in Phase 1b bringing the total recruitment, including Phase 1a, to 36 patients in the trial. All current patients in Phase 1b are being treated with new extended dosing of OVM-200, that was first suggested by the clinical investigators in the trial, following the excellent safety record seen in Phase 1a. The new regime allows up to 11 vaccinations of OVM-200 over a six-month period and has been approved by the UK Medicines and Healthcare products Regulatory Agency (MHRA). OVM-200 is a new cancer vaccine developed using OVM’s novel recombinant overlapping peptide (ROP) platform. It targets survivin, a protein overexpressed by cancer cells, which prevents them being attacked by the body’s immune system.
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The Phase I trial of OVM-200 is focused on safety and on establishing an immune response in patients with three tumour types – non small cell lung cancer (NSCLC), prostate cancer and ovarian cancer. It is being run at four sites in the UK including the Sarah Cannon Institute and University College London Hospital (UCL), the Churchill hospital of the Oxford University Hospitals Foundation Trust (OUHFT) and the Christie NHS Foundation Trust in Manchester. The first part of the trial , Phase 1a, has been completed and has shown both excellent safety and a strong immune response. The Chief Investigator for the trial is Professor Martin Forster, based at UCL Cancer Institute. This trial is the first time any ROP based vaccine has been tested in the clinic.
William Finch, CEO of Oxford Vacmedix, said:
We are delighted to have completed recruitment in the OVM-200 Phase 1 trial in such a short time after implementing the extended dosing protocol. This demonstrates both confidence in our novel technology and the huge unmet need that there is for effective new immunotherapies. We look forward to seeing the results in these critically ill patients.
Professor Martin Forster, Chief Investigator at University College London Hospital, added:
We are very pleased to see the progress of the trial. The results from Phase 1a showed excellent safety and a strong immune response. We are hoping that extended dosing will produce a very durable immune response for our patients and maximise the potential benefits of this new form of immunotherapy.