On October 3, 2017 Vium reported the selection of OncoSynergy, a UCSF oncology therapeutics spinout, as the first recipient of its "Next Generation Disease Model Grant" of $100,000 worth of research services (Press release, OncoSynergy, OCT 3, 2017, View Source [SID1234520773]). The companies will collaborate on a study of OncoSynergy’s lead drug candidate OS2966 to facilitate development of an optimized and clinically relevant experimental model of malignant ascites (MA), a complication of metastatic ovarian cancer (OC) associated with poor prognosis. The study will be the first to collect in-depth quality of life (QOL) metrics using an established experimental model of MA.
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OncoSynergy has already demonstrated efficacy of OS2966, its lead monoclonal antibody therapeutic candidate designated as an Orphan Drug by the U.S. Food and Drug Administration (FDA), in multiple models of OC, including alleviation of clinical signs of MA. The new study will therefore use Vium’s Smart Housing to increase the therapeutic window to more closely model disease progression in humans, thereby yielding more accurate measurement of disease metrics and improved tracking of QOL measures.
"We are pleased to collaborate with OncoSynergy and to fund this innovative study in a disease area with high unmet research and treatment needs," said Vium Chief Scientific Officer David Hutto, Ph.D, DVM, DACVP. "It’s a great match for Vium, as it allows us to apply our fully automated, low-touch technology and novel digital metrics to continuously assess changes in ovarian cancer-related malignant ascites — signs that would be difficult to evaluate using traditional methods."
"We believe the ability to continuously collect multimodal data noninvasively will be a game-changer for oncology studies, in which the current standard for decades has been binary," commented W. Shawn Carbonell, MD, Ph.D, co-founder and CEO of OncoSynergy. "We are excited to work with Vium to develop this novel and more humane approach to studying animal models of orphan malignancies such as ovarian cancer and glioblastoma, as these diseases are our main focus."