On November 17, 2025 Propanc Biopharma, Inc. (Nasdaq: PPCB) ("Propanc" or the "Company"), a biopharmaceutical company developing novel treatments for recurrent and metastatic cancer, reported an update on corporate progress and reported financial results for the first quarter ended September 30, 2025 (Year end June 30).

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Corporate and R&D Highlights

Advancing PRP Toward Phase 1b First-in-Human Trial (2026)

Propanc continues to advance its lead candidate, PRP, toward a world-first Phase 1b clinical study in 30–40 patients with advanced solid tumors at the Peter Mac Cancer Center in Melbourne. GMP manufacturing scale-up, analytical method validation, and preparation of the Investigator’s Brochure and Clinical Trial Application are underway. Purification processes have been successfully scaled, delivering >95% purity to pharmaceutical standards. Two related patents are in drafting.

Progressing Rec-PRP Synthetic Program

Rec-PRP, a fully synthetic recombinant version of PRP designed for improved stability and global scalability, is undergoing biological validation against the bovine-derived formulation. Supporting research has identified methods enabling large-scale production, with patent drafting in progress. Rec-PRP will enter formal preclinical development following potency evaluation.

POP1 Joint Research Program Extension

Propanc is negotiating a 12-month extension with the Universities of Jaén and Granada to expand the POP1 research program. Recent findings show PRP significantly reduces tumorigenicity in Gemcitabine-resistant pancreatic cancer and modulates malignant cells toward a less aggressive phenotype. Additional patents are being prepared based on these results.

Corporate and Financial Updates

Nasdaq Listing & Public Offering

The Company closed an underwritten public offering of 1,000,000 shares at $4.00 per share, raising gross proceeds of $4 million. Propanc’s common stock began trading on the Nasdaq Capital Market on August 15.

$100 Million Private Placement Facility

Propanc entered into a private placement agreement for up to $100 million to accelerate clinical development. The Company received an initial $1 million investment upon issuance of 100 shares of Series C Convertible Preferred Stock.

Q1 Financial Summary (Quarter Ended September 30, 2025)

Total current assets: $17 million
Total current liabilities reduced by $2 million
Net cash from financing activities: $2.53 million
Quarter-end cash: $600,000
$1 million initial tranche from the Series C facility subsequently received
The Company expects the financing facility to support planned R&D activities, including advancement of PRP and Rec-PRP.

Management Commentary

"Our first quarter delivered meaningful progress across clinical, financial, and strategic initiatives," said James Nathanielsz, CEO of Propanc. "We are focused on initiating the Phase 1b PRP clinical trial, advancing Rec-PRP into preclinical development, and expanding our IP portfolio. With our recent Nasdaq uplisting and long-term financing facility, we are well-positioned to accelerate commercialization of our proenzyme technology."

(Press release, Propanc, NOV 17, 2025, View Source [SID1234660031])