On March 17, 2026 Immunitas Therapeutics ("Immunitas"), a clinical stage precision immunotherapy company committed to discovering and developing novel, antibody-based therapeutics for patients with autoimmune diseases and cancer, reported it will present clinical data from its Phase 1/2a trial of first-in-class anti-CD161 antibody, IMT-009, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, held April 17-22, 2026 in San Diego, California. Data to be presented support continued development of IMT-009 as a novel cancer immunotherapy for treatment of solid tumors and hematologic malignancies.
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Presentation Details
Title: A first-in-human, dose escalation (DE) and biomarker cohort expansion (BCE) of IMT-009 (IMT) in advanced cancer and Phase 1b (Ph1b) combination with fruquintinib (F) in microsatellite stable colorectal cancer (MSS CRC)
Presenting Author: Susanna V. Ulahannan, M.D., The University of Oklahoma, Stephenson Cancer Center/SCRI
Abstract Number: CT048
Session: First-in-Human Phase I Clinical Trials
Location: Poster Section 50
Date & Time: Monday, April 20, 2026, 9:00 a.m. – 12:00 p.m. PT
About IMT-009
IMT-009 is a fully human, Fc-attenuated IgG1 monoclonal antibody that binds to CD161 and blocks its interaction with its ligand, CLEC2D. Preclinical data confirm that CD161 blockade with IMT-009 results in enhanced anti-tumor activity. IMT-009 is under evaluation in a Phase 1/2a clinical trial for use as a monotherapy and combination treatment for solid tumor and hematological malignancies. The Phase 1 study is designed to evaluate the safety, tolerability, pharmacodynamic biomarkers, and preliminary efficacy of IMT-009 as well as identify the Recommended Phase 2 Dose (RP2D).
(Press release, Immunitas Therapeutics, MAR 17, 2026, View Source [SID1234663639])