Regarding Discontinuation of Administration of “Tazverik® Tablets 200mg” (tazemetostat hydrobromide)

On March 18, 2026 Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, "Eisai") reported that the administration of the anticancer agent EZH2 inhibitor "Tazverik Tablets 200 mg" (generic name: tazemetostat hydrobromide), which is manufactured and marketed in Japan by Eisai should be discontinued. We plan to discontinue sales of this product once we have confirmed that it is no longer being administered to any patients.

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Following the announced voluntarily withdrawal of this product in the United States and other countries, Eisai has been collecting and reviewing safety data, including from the overseas clinical trials including SYMPHONY-1*1 and postmarketing data both domestic and from overseas. Based on the review of the available safety data, multiple cases of secondary hematologic malignancies have occurred on both combination and monotherapy treatment with tazemetostat.

After a comprehensive evaluation of these findings, we concluded that it is necessary to give the fullest possible consideration to the risk of secondary hematologic malignancies occurring even under the approved conditions of use in Japan.

Prioritizing patient safety, we are communicating with medical institutions in Japan where the drug is prescribed to consider discontinuing Tazverik immediately for patients currently receiving it, and to refrain from initiating any new administration.

Eisai will continue to make every effort to provide timely and appropriate information to healthcare professionals to prevent any confusion or disruption for medical institutions or patients.

(Press release, Eisai, MAR 18, 2026, View Source [SID1234663699])