On March 25, 2026 Caris Life Sciences (NASDAQ: CAI), a leading, patient-centric, next-generation AI TechBio company and precision medicine pioneer, reported that the Caris Precision Oncology Alliance (Caris POA) and collaborators from leading cancer centers, will collectively present six studies at the 2026 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting in San Diego, California to be held April 17-22, 2026.
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These studies leveraged Caris’ robust multimodal database, which integrates Whole Exome Sequencing (WES), Whole Transcriptome Sequencing (WTS), immunohistochemistry (IHC) and real world clinical data, to generate clinically meaningful insights across multiple tumor types. This research reflects Caris’ commitment to advancing precision oncology through deep molecular interrogation. The studies focused on breast, prostate, lung and colorectal cancers represent a collaborative effort between Caris and leading cancer centers and institutions, underscoring the power of large‑scale, real world molecular evidence to accelerate discovery and improve patient outcomes.
"These studies demonstrate the transformative potential of multimodal molecular data to uncover clinically meaningful patterns that would otherwise remain hidden," said James Hamrick, MD, MPH, Chairman of the Caris POA. "By combining deep genomic profiling with real world clinical evidence, Caris and its collaborators are generating insights that can directly inform treatment decisions and accelerate the development of more effective therapies for patients."
Posters Include:
Spatially resolved tumor-cell MHC class II shapes adaptive immunity and therapeutic response in triple-negative breast cancer
Session: Spatial Proteomics and Transcriptomics 1
Sunday, April 19, 2026, 2:00 PM – 5:00 PM PST
Poster #: 1200/1
Location: Poster section 47
Prognostic and predictive effects of TP53 co-mutations and RET fusion partners in RET-rearranged advanced NSCLC
Session: Biomarkers Predictive of Therapeutic Benefit 3
Monday, April 20, 2026, 9:00 AM – 12:00 PM PST
Poster #: 2434/4
Location: Poster section 40
AR copy number amplification and AR/KLK3 expression patterns reveal mechanisms of AR signaling inhibitor (ARSI) resistance and highlight the need for AR-directed therapeutic innovation in metastatic castration resistance prostate cancer (mCRPC)
Session: Molecular Targeted Therapy
Monday, April 20, 2026, 2:00 PM – 5:00 PM PST
Poster #: 3910/16
Location: Poster section 47
cBioPortal for cancer genomics
Session: AACR (Free AACR Whitepaper) Project GENIE: Genomic Characterization
Tuesday, April 21, 2026, 9:00 AM – 12:00 PM PST
Poster #: 4097/2
Location: Poster section 1
Distinct KRAS mutation codons differentially associate with microsatellite instability in colorectal carcinoma
Session: Precision Oncology and Real World Data
Tuesday, April 21, 2026, 9:00 AM – 12:00 PM PST
Poster #: 5336/4
Location: Poster section 46
MCM2 and the origin licensing complex: A putative node of ER+/HER2- breast cancer therapy resistance
Session: Real World Data to Provide Real World Evidence
Tuesday, April 21, 2026, 2:00 PM – 5:00 PM PST
Poster #: 6647/16
Location: Poster section 47
Research highlights will be available onsite at Caris’ booth #1423. The full abstracts will be available on the Caris website following the presentations.
(Press release, Caris Life Sciences, MAR 25, 2026, View Source [SID1234663913])