On April 16, 2026 Myriad Genetics, Inc. (NASDAQ: MYGN), a leader in molecular diagnostic testing and precision medicine, reported that it will share six abstracts, including two podium presentations, at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2026.
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"AACR is one of the premier forums for oncology research, and we are excited to share the depth of work underway across our MRD and hereditary cancer programs, including two podium presentations demonstrating the exceptional performance of Precise MRD, Myriad’s tumor-informed, ultrasensitive MRD assay," said Dale Muzzey, PhD, Chief Scientific Officer, Myriad Genetics.
The company will share new results from the MONITOR-Breast study, a prospective, multi-center clinical trial evaluating the performance of Precise MRDTM in breast cancer across all phases of the treatment journey. The data will be shared in a podium presentation on Monday, April 20, 2026 by Dr. Julia Foldi, MD, PhD, University of Pittsburgh Medical Center Hillman Cancer Center. These results expand on the study’s early insights presented at the San Antonio Breast Cancer Symposium in December 2025, including results from a large cohort of patients receiving neoadjuvant therapy with frequent MRD assessment, providing the first high-temporal resolution characterization of ctDNA dynamics in all breast cancer subtypes during neoadjuvant treatment.
"Breast cancer treatment has evolved significantly, but clinicians still face real challenges in assessing how well a patient is responding to therapy in the neoadjuvant setting," said Dr. Foldi. "The data being presented at AACR (Free AACR Whitepaper) reveal distinct response patterns that are associated with pathological response and demonstrate that frequent, ultrasensitive MRD testing can provide personalized information about treatment effectiveness. MONITOR-Breast is generating important clinical evidence for Precise MRD in breast cancer that could help oncologists personalize treatment decisions for their patients."
Additionally, Dr. Ranjan Upadhyay from The University of Texas MD Anderson Cancer Center will present the results of a phase II clinical trial. Together, these results from clinical trials continue to build and expand the evidence supporting the performance of the Precise MRD test in breast cancer treatment and surveillance.
The following abstracts will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting on April 17-22, 2026, at the San Diego Convention Center in San Diego.
Myriad Genetics Presentations
Session CTMS04 – Focus on ctDNA
Early findings from MONITOR-Breast: ctDNA dynamics during neoadjuvant therapy using an ultrasensitive MRD assay
Podium; Abstract Presentation Number: CT171
Mon., April 20 – 2:50 – 3:00 pm, Hall H – Ground Level – Convention Center
Presenter: Julia Foldi, MD, PhD, University of Pittsburgh Medical Center
Session CTMS04 – Focus on ctDNA
A phase II trial of adjuvant PD-1 blockade with endocrine therapy in hormone receptor positive inflammatory breast cancer: Circulating biomarkers and molecular correlates of clinical outcomes
Podium; Abstract Presentation Number: CT172
Mon., April 20 – 3:05 – 3:15 pm PST, Hall H – Ground Level – Convention Center
Presenter: Ranjan Upadhyay, MD, PhD, The University of Texas MD Anderson Cancer Center
Liquid Biopsies: Circulating Nucleic Acids 2
Analytical validation of an ultra-high sensitivity tumor-informed MRD assay
Poster Board Number: 2598
Mon., April 20 – 9:00 am – 12:00 pm PST
Presenter: Ashley Acevedo, PhD, Myriad Genetics
Genetic Epidemiology 1: GxE, GWAS, Polygenic Risk Scores, and Post-GWAS
Independent validation of polygenic risk scores for overall and triple-negative breast cancer among high-risk African American women
Poster Board Number: 3587
Mon., April 20 – 2:00 – 5:00 pm PST
Presenter: Dezheng Huo, PhD, University of Chicago
Liquid Biopsies: Circulating Nucleic Acids 4
Fragmentomic analysis of cfDNA WGS at regulatory regions generates gene-level expression-like traits for subtype analysis in breast cancer
Poster Board Number: 5313
Tues, April 21 – 9:00 am – 12 pm PST
Presenter: James Davison, PhD, GeneCentric Therapeutics, Inc.
Phase I and Phase II Clinical Trials in Progress
A pragmatic study of the clinical utility of genomic classifiers in guiding prostate cancer treatment decisions: Impact of treatment selection, oncologic outcomes, and treatment-related adverse events (PROMPT-Bx)
Poster Board Number: 14; Abstract Presentation Number: CT280
Tues., April 21 – 2:00-5:00 pm PST
Presenter: Matthew Schiewer, PhD, Myriad Genetics
Conference Highlights
Myriad will welcome attendees to its booth (#3747) during exhibition hours. Myriad tests to be highlighted at the conference booth include:
Precise MRD (Molecular Residual Disease) Test is a tumor-informed assay that uses whole genome sequencing (WGS) to achieve ultra-sensitivity. This unique assay enables the custom selection of up to 1,000 targeted variants for deep analysis. It has impressive limits of detection and sensitivity.1 The test can be used to monitor circulating tumor DNA (ctDNA) levels throughout a patient’s clinical cancer care, starting immediately after diagnosis and continuing through treatment and surveillance.
MyRisk Hereditary Cancer Test with RiskScore combines genetics, clinical factors (Tyrer-Cuzick), and polygenic risk to uncover insights that gene testing alone may not provide, helping offer more information to support patient decisions in breast cancer risk assessment and management.
Prolaris Prostate Cancer Prognostic Test is a molecular diagnostic test that provides personalized information about the aggressiveness of a patient’s prostate cancer, helping to identify whether it is safe to forgo treatment, whether to pursue treatment, and how much treatment is needed for the best possible outcome. Prolaris is the only biomarker test to quantify the benefits of adding androgen ADT to RT.
The booth will feature Myriad’s Biopharma services which are utilized for working in conjunction with Biopharma partners to advance drug development programs from biomarker discovery through CTA, CDx development, worldwide regulatory approval and global commercialization, including:
MyChoice CDx is the only FDA-approved homologous recombination deficiency (HRD) test specifically mentioned in ASCO (Free ASCO Whitepaper) guidelines for selecting patients with ovarian cancer who may benefit from PARP inhibitors.1 By determining comprehensive HRD status, the MyChoice CDx Test helps expand access to targeted therapy in both early and late-line settings.
MSK-ACCESS is a comprehensive liquid biopsy test developed by Memorial Sloan Kettering Cancer Center (MSK). The test offers noninvasive cancer genomic profiling and disease monitoring using cell-free DNA (cfDNA) obtained from blood and other body fluids. The test is currently available for use in conjunction with Myriad’s Pharma partnerships for CTA development and CDx utilizing Myriad’s partnership with SOPHiA GENETICS.
MSK-IMPACT is a solid tumor test for comprehensive genomic profiling (CGP) which delivers high-resolution profiling of complex biomarkers from DNA and RNA in a single, end-to-end workflow. The test is currently available for use in conjunction with Pharma partnerships for CTA development and CDx utilizing Myriad’s partnership with SOPHiA GENETICS.
Myriad Genetics will also participate in the Exhibitor Spotlight Theater: "Advances in ctDNA Testing towards Biopharma Development & Clinical Dx" on Sun., April 19 from 3:30 – 4:30 pm in Theater B. The Spotlight Theater will highlight Myriad’s latest developments for Precise MRD, as well as the results of Myriad’s collaboration with GeneCentric Therapeutics and its ExpressCT liquid biopsy technology.
References:
Tew WP, Lacchetti C, Birrer MJ, et al. PARP inhibitors in the management of ovarian cancer: ASCO (Free ASCO Whitepaper) guideline. J Clin Oncol. 2020;38(30):3468-3493.
About the MONITOR-Breast Study
MONITOR-Breast is a prospective, multicenter observational study evaluating patients with Stage I-III breast cancer across all subtypes. The study systematically assessed ctDNA using Precise MRD, a tumor-informed whole-genome sequencing (WGS)-based assay, at frequent intervals during neoadjuvant therapy, with a median of 9 timepoints per patient. This design enabled a high-resolution, longitudinal analysis of ctDNA dynamics across the neoadjuvant treatment course.
(Press release, Myriad Genetics, APR 16, 2026, View Source [SID1234664457])