On June 4, 2026 NextCure, Inc. (Nasdaq: NXTC), a clinical-stage biopharmaceutical company committed to discovering and developing novel therapies to treat cancer, reported the replay availability for its virtual key opinion leader (KOL) event on SIM0505, held following the Company’s ASCO (Free ASCO Whitepaper) 2026 poster presentation of first reported clinical efficacy data from its Phase 1 dose escalation study (June 1, 2026 press release). SIM0505 is an investigational antibody drug conjugate (ADC) targeting Cadherin-6 (CDH6) with a proprietary topoisomerase 1 inhibitor (TOPOi) payload. The virtual KOL Event is accessible here.
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The event featured:
Beryl Manning-Geist, MD (Emory University)
Ursula Matulonis, MD (NextCure Scientific Advisory Board and Dana-Farber Cancer Institute)
Rakesh Dixit, PhD, DABT (NextCure Scientific Advisory Board)
Discussion centered on first reported clinical efficacy data from the Phase 1 dose escalation study of SIM0505 in ovarian cancer and uterine serous carcinoma (USC), two gynecologic malignancies where effective treatment options remain limited.
About SIM0505 at the Annual Meeting of the American Society for Clinical Oncology (ASCO 2026)
Materials from NextCure’s ASCO (Free ASCO Whitepaper) 2026 activities are available on the Company’s website under Investor Relations, Events & Presentations:
ASCO Poster: View Source
ASCO Press Release: View Source
Virtual KOL Event Replay: View Source
Virtual KOL Event Presentation: View Source
Beryl Manning-Geist, MD is an assistant professor in the Division of Gynecologic Oncology in the Department of Gynecology and Obstetrics at Emory University School of Medicine. Dr. Manning-Geist specializes in treating patients with gynecologic cancers including uterine, ovarian and cervical cancers. She practices at Winship Cancer Institute at Emory Midtown. After working at the National Institutes of Health’s National Cancer Institute, Dr. Manning-Geist attended Emory University School of Medicine on a full scholarship as a Woodruff Scholar. There, she received her MD summa cum laude before completing her residency in obstetrics and gynecology at Harvard University’s Brigham and Women’s Hospital/Massachusetts General Hospital in Boston. She then completed her fellowship in gynecologic oncology at Memorial Sloan Kettering Cancer Center in New York
Ursula Matulonis, MD is Chief of the Division of Gynecologic Oncology at the Dana-Farber Cancer Institute and Professor of Medicine at Harvard Medical School. She is the first recipient of the Brock-Wilson Family Chair at the Dana-Farber Cancer Institute. Dr. Matulonis co-leads the Gynecologic Cancer Program within the Dana-Farber/Harvard Cancer Center and the Ovarian Cancer Specialized Program in Research Excellence (SPORE) grant from the National Cancer Institute. Her research is focused on developing new targeted therapies for gynecologic malignancies, with a specific interest in ovarian cancer and endometrial cancer. Dr. Matulonis earned her MD from the Albany Medical College.
Rakesh Dixit, PhD, DABT currently serves as President and CEO of Bionavigen, a biopharmaceutical company specializing in consulting and drug hunting for biologic, cell and gene therapy and small molecule drug development. He is also President and CSO of Regio Biosciences, an AstraZeneca Spinoff company. Dr. Dixit is an accomplished executive, inventor, and scientist with over 30 years of success with top biotechnology and pharmaceutical companies, including Merck, Johnson & Johnson, MedImmune, and AstraZeneca. He was a key contributor to successful approval of biotherapeutics, including five biologics (including antibodies and immunotoxins) and four small molecule pharmaceuticals. He was honored in 2020 by the World ADC Forum with its most prestigious award of Long-Standing Contributor to ADCs.
About SIM0505
SIM0505 is a novel ADC directed to CDH6, featuring a proprietary TOPOi payload. The ADC is designed for broad anti-tumor activity, fast systemic clearance and an improved potential therapeutic window. SIM0505 is being evaluated in an open-label, Phase 1 study (NCT06792552) for the potential treatment of advanced solid tumors, including ovarian cancer, with an emphasis on PROC. The U.S. Food and Drug Administration granted Fast Track Designation to SIM0505 for the treatment of PROC. NextCure holds exclusive global rights for SIM0505, excluding China, Hong Kong, Macau, and Taiwan which are retained by Simcere Zaiming.
(Press release, NextCure, JUN 4, 2026, View Source [SID1234666457])