On August 31, 2026 AIM ImmunoTech Inc. (NYSE American: AIM) ("AIM" or the "Company") reported that the United States Patent and Trademark Office has granted a patent covering the use of the Company’s drug Ampligen in combination with the PD-1 checkpoint inhibitor pembrolizumab for the treatment of cancer. This newly issued U.S. patent expires December 20, 2039.
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Ampligen is a wide-spectrum Toll-like receptor 3 (TLR3) agonist, among other biological effects, and has been investigated for the treatment of various cancers, among other conditions. The Company has been issued multiple patents, and has filed multiple additional patent applications, directed to the use of Ampligen for cancer treatment.
"The issuance of this patent marks another significant step in building a broad and durable intellectual property patent estate around Ampligen’s potential role in cancer immunotherapy," said Thomas Equels, Chief Executive Officer of AIM ImmunoTech. "This patent protects Ampligen’s use in combination therapy with the leading PD-1 checkpoint therapy across a broad range of cancers and specifically encompasses pancreatic cancer, the central focus of our late-stage oncology strategy. Together with our existing U.S. and international patents covering Ampligen with PD-1 and PD-L1 checkpoint blockade, we believe this growing patent estate strengthens both the scientific and strategic foundation supporting Ampligen’s long-term oncology opportunity."
The newly issued patent’s broadest claim covers methods of treating cancer, by giving Ampligen together with pembrolizumab, whether administered at the same time or at different times, where the combination produces a greater effect against the cancer than either treatment alone, or than would be expected simply by adding their individual effects together. Other claims in the patent specifically name pancreatic cancer, skin cancer, colorectal cancer, ovarian cancer, melanoma, breast cancer, triple negative breast cancer, head and neck tumor, bladder cancer, renal cell carcinoma, and lung cancer as types of cancers for which the combination use is claimed in the patent, but the broad claim’s coverage is not limited to any cancer.
AIM also holds a U.S. patent, expiring August 9, 2039, covering methods of using Ampligen as part of a combination oncology therapy paired with an anti-programmed death-ligand 1 (PD-L1) antibody; a Netherlands patent, expiring December 19, 2039, broadly covering the use of Ampligen as a combination cancer therapy with PD-1 and PD-L1 checkpoint blockade inhibitors; and a Japanese patent, expiring December 20, 2039, covering the use of Ampligen in combination with either anti-PD-1 or anti-PD-L1 antibodies for the treatment of cancer.
(Press release, AIM ImmunoTech, AUG 31, 2026, View Source [SID1234670438])