On October 20, 2026 CPTx, a company developing next-generation non-viral in vivo CAR T therapies, reported that it will present new findings from its preclinical studies at the 33rd Annual Congress of the European Society of Gene and Cell Therapy (ESGCT), taking place in Hamburg, Germany, from October 27-30, 2026.
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The presentations will feature new efficacy data from rodent studies and first safety data from non-human primate (NHP) studies evaluating CPTx’s fully non-viral in vivo CAR T platform. The platform combines proprietary immune-quiet hybrid DNA with targeted lipid nanoparticles (tLNPs) to program CAR T cells directly inside the patient.
Together, the new efficacy and safety data represent an important step in the platform’s preclinical development toward clinical translation.
"Building on the encouraging preclinical evidence generated to date, we are focused now on translating our DNA-based in vivo CAR T platform toward first-in-human studies." – Hendrik Dietz, PhD, Founder and CEO of CPTx.
Details of the presentation:
Oral Presentation OR082: Targeted immune-silent ssDNA-tLNP delivery enables in vivo CAR-T generation and eradication of disseminated tumors
Session: 12d – Non-viral vectors/Nanotechnology and RNA therapeutics II
Presenter: Matthias Bozza
Date and time: Friday, October 30th, 12:30 – 12:45 pm
Location: Hall 4, Level 0, Congress Center Hamburg
Poster P0370: Advanced characterization of ssDNA-loaded targeted lipid nanoparticles for in vivo CAR T cell therapy
Session: Poster Session II
Presenter: Nadja Berger
Date and time: Thursday, October 29th, 2:00 – 4:00 pm
Location: Poster Halls, Congress Center Hamburg
(Press release, CPTx Bio, OCT 20, 2026, View Source [SID1234673630])