On November 5, 2026 Nurix Therapeutics, Inc. (Nasdaq: NRIX), a clinical-stage biopharmaceutical company focused on the discovery, development and commercialization of targeted protein degradation medicines, reported that new and updated clinical data from its ongoing Phase 1a/1b study evaluating bexobrutideg (NX-5948), the Company’s investigational oral Bruton’s tyrosine kinase (BTK) degrader, will be presented in a poster session at the 68th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting and Exposition, being held December 12-15, 2026 in New Orleans, Louisiana.
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The presentation abstract was released today by ASH (Free ASH Whitepaper) and highlights new and updated data in patients with relapsed/refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) with efficacy data reported for those previously treated with covalent BTK inhibitors (cBTKi). Results demonstrate continued evidence of durable clinical activity and favorable tolerability with bexobrutideg administered at the recommended Phase 2 dose of 600 mg once daily. Additional analyses, including data from BTK inhibitor-naïve and treatment naïve patients and efficacy in patients with high-risk molecular features, will be presented at the meeting.
"Patients with relapsed or refractory CLL/SLL continue to face significant challenges as resistance and intolerance emerge with currently available therapies," said Arthur T. Sands, M.D., Ph.D., president and chief executive officer of Nurix Therapeutics. "We are encouraged by the growing body of clinical evidence supporting bexobrutideg’s potential to address important unmet needs in patients at early as well as late stages of their therapeutic journeys. The updated data being presented at ASH (Free ASH Whitepaper) further underscore the differentiated mechanism of our BTK degrader, including its ability to target both wild-type and mutant forms of BTK, and reinforce our confidence in the ongoing development of bexobrutideg as a potential best-in-class therapy for patients with B-cell malignancies."
Poster Presentation Details
Title: New and updated efficacy and safety data on bexobrutideg (NX-5948), a novel BTK degrader, in patients with relapsed/refractory CLL/SLL and prior cBTKi exposure from an ongoing Phase 1a/b trial
Session Name: 642. Chronic Lymphocytic Leukemia: Clinical and Epidemiological: Poster II
Presenter: Nirav Shah, M.D., Medical College of Wisconsin
Session Date: December 13, 2026
Presentation Time: 12/13/2026 6:00:00 PM – 12/13/2026 8:00:00 PM
Room: Hall F
About Bexobrutideg (NX-5948)
Bexobrutideg (NX-5948) is an investigational, orally bioavailable, brain-penetrant, highly selective small-molecule degrader of Bruton’s tyrosine kinase (BTK) being developed by Nurix and Roche as a potential best-in-class therapy across oncology, immunology and neurology.
Bexobrutideg is currently being evaluated in a broad clinical development program in patients with CLL, including the DAYBreak CLL-201 clinical trial (NCT07221500), a pivotal single-arm Phase 2 study in patients with relapsed/refractory CLL previously treated with covalent and noncovalent BTKi and a BCL2i; the DAYBreak CLL-306 clinical trial (NCT07516093), a randomized Phase 3 trial comparing bexobrutideg to pirtobrutinib in patients with relapsed/refractory CLL previously treated with a covalent BTKi; the NX-5948-203 Phase 1b/2 clinical trial (NCT07520006), assessing the combination of bexobrutideg with venetoclax in patients with relapsed/refractory CLL and potentially treatment-naïve CLL; and the NX-5948-301 Phase 1a/1b clinical trial (NCT05131022) in patients with relapsed/refractory B-cell malignancies. Additional information about these clinical trials can be found at clinicaltrials.gov.
(Press release, Nurix Therapeutics, NOV 5, 2026, View Source [SID1234674371])