Syros to Present New Preclinical Data on SY-1365 and on Identification of Potential Drug Targets in Triple Negative Breast Cancer at San Antonio Breast Cancer Symposium

On November 13, 2017 Syros Pharmaceuticals (NASDAQ: SYRS), a biopharmaceutical company pioneering the discovery and development of medicines to control the expression of disease-driving genes, reported that the Company will present new preclinical data identifying potential biomarkers predictive of response to SY-1365, its first-in-class selective cyclin-dependent kinase 7 (CDK7) inhibitor currently in a Phase 1 clinical trial in advanced solid tumors, at the San Antonio Breast Cancer Symposium (SABCS) taking place December 5-9 in San Antonio (Press release, Syros Pharmaceuticals, NOV 13, 2017, View Source [SID1234522012]). The Company will also present on the use of its gene control platform to analyze regulatory regions of the genome in triple negative breast cancer cells and identify potential new drug targets.

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Details on the presentations are as follows:

Date & Time: Wednesday, December 6, from 5-7 p.m. CST
Presentation Title: BCL2L1 (BCL-XL) expression and MYC super-enhancer positivity predict sensitivity to the covalent CDK7 inhibitor SY-1365 in triple negative breast cancer (TNBC) cell lines
Session Title: Treatment: Novel Targets and Targeted agents
Presenter: Nisha Rajagopal, Ph.D., Senior Scientist, Syros
Abstract Number: 1343
Location: Henry B. Gonzalez Convention Center, Hall 1

Date & Time: Thursday, December 7, from 7-9 a.m. CST
Presentation Title: Epigenomic analysis of cancer stem cell (CSC)-enriched triple-negative breast cancer (TNBC) populations reveals gene regulatory circuitry and novel tumor cell vulnerabilities
Session Title: Tumor cell and molecular biology: Epigenetics
Presenter: Matthew Guenther, Ph.D., Principal Scientist, Syros
Abstract Number: 1548
Location: Henry B. Gonzalez Convention Center, Hall 1