On May 16, 2018 Innate Pharma SA (the "Company" – Euronext Paris: FR0010331421 – IPH) last night reported preliminary data from an ongoing Phase I dose escalation and expansion study evaluating the safety and efficacy of the combination of monalizumab, a first-in-class monoclonal antibody targeting NK- and T cell checkpoint receptor NKG2A, with durvalumab (Press release, Innate Pharma, MAY 16, 2018, View Source [SID1234526741]).
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Data show preliminary anti-tumor activity in patients with recurrent, metastatic colorectal cancer, with 3 partial responses and 11 stable disease responses among 37 patients evaluable for efficacy, with a disease control rate of 24% at 16 weeks (data cut as of February 8, 2018). The data also showed a manageable toxicity profile.
The Phase I dose escalation and expansion study enrolled a total of 55 patients. In the dose-escalation part, 15 patients with selected solid tumors received durvalumab 1500 mg every 4 weeks in combination with monalizumab at increasing doses. In the expansion phase, 40 patients with microsatellite-stable colorectal cancer (MSS-CRC) were enrolled. 58% of patients in expansion had 3+ lines of prior therapy.
These data were highlighted in an abstract (#3540) published online on May 16 by the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) in advance of its annual meeting in Chicago, Illinois, June 1-5, 2018. The abstract is available on the ASCO (Free ASCO Whitepaper) website. A poster (#33) with updated clinical data will be presented at ASCO (Free ASCO Whitepaper) in the Gastrointestinal (Colorectal) Cancer session in Hall A on Sunday, June 3 between 8:00am and 11:30am.
Based on these preliminary results, Innate’s partner AstraZeneca/MedImmune progressed the combination with standard of care therapies