On June 2, 2018 NantWorks, LLC reported that its affiliate companies, NantHealth, Inc., (NASDAQ: NH), a leading next-generation, evidence-based, personalized healthcare company and NantOmics, LLC, the leader in molecular analysis and a member of the NantWorks ecosystem of companies, will present findings on how targeting immune checkpoints and employing combinations has led to clinical benefit across a variety of tumor types during the tumor biology session at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2018 Annual Meeting, an event bringing together 30,000 oncology professionals from June 1-5, 2018 at McCormick Place in Chicago, Illinois (Press release, NantHealth, JUN 2, 2018, View Source;p=RssLanding&cat=news&id=2352872 [SID1234527097]). NantWorks will be exhibiting at booth #7147 during the event.
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"We are excited to share data on how profiling the tumor and associated microenvironment can help tailor rational combinations of immunotherapeutic strategies," said Patrick Soon-Shiong, MD, founder of NantWorks. "This data is an important step in enhancing response rates through individualized immune checkpoints in PD-L1 expression, and we look forward to continued exploration and potential solutions for patients."
Presentation Details
Co-expression patterns of immune checkpoint molecules in relation to PD-L1 expression, Abstract #12113
WHO: NantHealth, LLC and NantOmics, LLC
WHAT: Tumor Biology Session
WHEN: June 4, 1:15-4:45 PM CST
WHERE: Hall A, McCormick Place
Presentation Summary
In order to determine if tailored rational combinations of immunotherapeutic strategies can be achieved by profiling the tumor and associated microenvironment, whole transcriptomic sequencing of 1,880 unselected clinical cases, reflecting 38 distinct histologies, was performed. Cases were categorized as PD-L1-low, PD-L1-normal and PD-L1-high by cutoffs defined in TCGA expression profiles. The results found that high and low PD-L1 expression in the tumor and adjacent microenvironment are associated with variations in key checkpoint molecules. The results also found that low expression of PD-L1 may be an ideal setting for use of IDO- or TIM3-directed therapies.