On April 2, 2014 Patrys reported that data on the production of PAT-SM6 in an easy-to-grow plant manufacturing system have been published in the leading peer-reviewed journal Proceedings of the National Academy of Sciences (PNAS) (Press release Patrys, APR 2, 2014, View Source [SID:1234500550]). The article titled "Expression and glycoengineering of functionally active hetero-multimeric IgM in plants" is currently available online ahead of a future print edition of the journal.
The study was the result of a research collaboration involving Patrys and the University of Natural Resources and Life Sciences, Vienna, Austria. The collaboration has focused on developing an alternative production system for the manufacture of IgM antibodies (using PAT-SM6) which might significantly reduce production costs while maintaining the quality and functionality of the antibody products.
The study found that relatively high quantities of PAT-SM6 IgM antibody can be made in an easy-to-grow plant manufacturing system. Further, functionality of antibodies very often depends on the attached sugars. It was shown that by modulating the properties of the plants, a process called in planta glycoengineering, this plant expression system can produce fully functional antibodies that are similar to the antibodies generated by the human body. The study demonstrated this novel plant-based process can be successfully applied to generate high yield, functional, human-like IgM antibodies.

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