On June 9, 2016 AbbVie (NYSE: ABBV), a global biopharmaceutical company, reported data on its investigational medicine venetoclax, a B-cell lymphoma -2 (BCL-2) inhibitor, and duvelisib, an investigational phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma inhibitor, at the 21st European Hematology Association (EHA) (Free EHA Whitepaper) Annual Congress, June 9-12, in Copenhagen, Denmark (Press release, AbbVie, JUN 9, 2016, View Source [SID:1234513157]). Data will be presented in some of the most common hematological malignancies, including chronic lymphocytic leukemia (CLL), multiple myeloma (MM), acute myeloid leukemia (AML) and follicular lymphoma.
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"BCL-2 inhibition is an exciting new mechanism of action and the data that will be presented demonstrate venetoclax’s potential across a range of blood cancers," said Michael Severino, M.D., executive vice president of research and development and chief scientific officer, AbbVie. "The data underscore AbbVie’s growing hematology portfolio and our commitment to changing the way blood cancer is treated with innovative new treatment options."
The 10 venetoclax abstracts and one duvelisib abstract that will be presented at EHA (Free EHA Whitepaper) demonstrate how AbbVie is utilizing its deep expertise to explore novel mechanisms of action and administration to disrupt cancer development and growth in blood cancers.
AbbVie abstracts:
Venetoclax in CLL
Impact of adding rituximab to venetoclax on the rate, quality and duration of response in patients with relapsed/refractory chronic lymphocytic leukemia: a cross-study multivariable analysis; Roberts et al.; Abstract P209; Poster Session; Friday, June 10, 2016; 5:15-6:45 p.m. CET
Durable treatment-free remission and effective retreatment in patients with relapsed/refractory chronic lymphocytic leukemia who achieved a deep response with venetoclax combined with rituximab; Brander et al.; Abstract P223; Poster Session; June 10, 2016; 5:15-6:45 p.m. CET
Safety, efficacy and immune effects of venetoclax 400 mg daily in patients with relapsed chronic lymphocytic leukemia; Anderson et al.; Abstract P591; Poster Session; Saturday, June 11, 2016; 5:30-7:00 p.m. CET
Integrated safety analysis of venetoclax monotherapy in chronic lymphocytic leukemia; Davids et al.; Abstract P225; Poster Session; Friday, June 10 2016; 5:15-6:45 p.m. CET
Venetoclax is active in CLL patients who have relapsed after or are refractory to ibrutinib or idelalisib; Coutre et al.; Abstract P599; Poster Session; Saturday, June 11 2016; 5:30-7:00 p.m. CET
Interim quality of life results with venetoclax (ABT-199/GDC-0199) monotherapy in patients with relapsed/refractory del(17p) chronic lymphocytic leukemia; Wierda et al.; Abstract P426; Poster Session; Friday, June 10, 2016; 5:15-6:45 p.m. CET
Venetoclax in AML
Results of a phase 1b study of venetoclax plus decitabine or azacitidine in untreated acute myeloid leukemia patients ?65 years ineligible for standard induction therapy; Pollyea et al.; Abstract P192; Poster Session; Friday, June 10, 2016; 5:15-6:45 p.m. CET
Phase 1b/2 study of venetoclax with low-dose cytarabine in treatment-naïve patients aged ?65 years with acute myelogenous leukemia; Lin et al.; Abstract E911; ePOSTER
Venetoclax in MM
Phase 1b study of venetoclax combined with bortezomib and dexamethasone in relapsed/refractory multiple myeloma; Moreau et al.; Abstract P272; Poster Session; Friday, June 10, 2016; 5:15-6:45 p.m. CET
Phase 1 study of venetoclax monotherapy for relapsed/refractory multiple myeloma; Kumar et al.; Abstract S814; Oral Presentation; Sunday, June 12, 2016; 8:15-8:30 a.m. CET
Duvelisib in Follicular Lymphoma
Preliminary safety, pharmacokinetics, and pharmacodynamics of duvelisib plus rituximab or obinutuzumab in patients with previously untreated CD20+ follicular lymphoma; Casulo et al.; Abstract P319; Poster Session; Friday, June 10, 2016; 5:15-6:45 p.m. CET
Meeting abstracts are available at www.ehaweb.org.
For more information about CLL, please visit View Source
About Venetoclax
Venetoclax is an investigational oral B-cell lymphoma-2 (BCL-2) inhibitor being evaluated for the treatment of patients with various blood cancer types.[1],[2],[3],[4] The BCL-2 protein prevents apoptosis (programmed cell death) of some cells, including lymphocytes, and can be over expressed in some cancer types. Venetoclax is designed to selectively inhibit the function of the BCL-2 protein.[5] Venetoclax is being developed in collaboration with Genentech and Roche. Together, the companies are committed to BCL-2 research with venetoclax, which is currently being evaluated in Phase 3 clinical trials for the treatment of relapsed/refractory chronic lymphocytic leukemia (CLL), along with studies in several other cancers. AbbVie and Genentech will co-promote venetoclax in the U.S.; however, AbbVie has exclusive rights to venetoclax outside of the U.S.
About Duvelisib
Duvelisib is an investigational dual inhibitor of phosphoinositide-3-kinase (PI3K)-delta and PI3K-gamma, two proteins that are known to help support the growth and survival of malignant B-cells.[6] PI3K signaling may lead to the proliferation of malignant B-cells, and is thought to play a role in the formation and maintenance of the supportive tumor microenvironment.[6],[7] ,[8] AbbVie and Infinity Pharmaceuticals, Inc. are jointly researching and developing duvelisib in various cancer types.
Duvelisib is being evaluated in several studies, including a Phase 2 study in patients with refractory indolent non-Hodgkin lymphoma,[9] a Phase 3 study in combination with other agents in patients with previously treated follicular lymphoma,[10] and a Phase 3 study in patients with relapsed/refractory chronic lymphocytic leukemia.[11] Duvelisib is an investigational compound and its safety and efficacy have not been evaluated by the FDA or any other health authority.