On October 8, 2018 CytomX Therapeutics, Inc. (Nasdaq:CTMX) a clinical-stage oncology-focused biopharmaceutical company pioneering a novel class of investigational antibody therapeutics based on its Probody therapeutic technology platform, reported that additional clinical results from PROCLAIM-072, an ongoing Phase 1/2 trial evaluating CX-072, a Probody therapeutic targeting PD-L1, will be presented at the 2018 Annual Meeting of the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) (Press release, CytomX Therapeutics, OCT 8, 2018, View Source [SID1234529821]). The conference will take place from October 19-23 in Munich, Germany.
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Two posters will provide additional results from the ongoing monotherapy dose escalation arm and the combination arm with Yervoy (ipilimumab) of the PROCLAIM-CX-072 trial, each in patients with advanced unresectable solid tumors.
CytomX’s ESMO (Free ESMO Whitepaper) poster presentations will include longer follow-up periods from additional patients treated in both the monotherapy and combination arms, new patient data from the combination arm and will reflect a data cutoff approximately three months after the abstract data cutoff.
Poster 435P – Preliminary Results of PROCLAIM-CX-072: The First-In-Human, Dose-Finding Trial of PD-L1 Probody Therapeutic CX-072 as Monotherapy in Patients with Advanced Solid Tumors
Presenter: Valentina Boni, M.D., Ph.D., START Madrid-CIOCC HM University Hospital Sanchinarro, Madrid, Spain
Date/Time: Monday, October 22, 12:45 p.m. – 1:45 p.m. CEST/ 6:45 a.m. – 7:45 a.m. EDT
Location: Hall A3
Poster 436P – Preliminary Results of the First-In-Human, Dose-Finding PROCLAIM-CX-072 Trial Evaluating the PD-L1 Probody Therapeutic CX-072 in Combination with Ipilimumab in Patients with Advanced Solid Tumors
Presenter: Ruth Plummer, M.D., Northern Centre for Cancer Care, Newcastle, United Kingdom
Date/Time: Monday, October 22, 12:45 p.m. – 1:45 p.m. CEST/ 6:45 a.m. – 7:45 a.m. EDT
Location: Hall A3
Poster abstracts can be located by searching The ESMO (Free ESMO Whitepaper) 2018 Online Program Session and using the Poster numbers above.
CytomX’s posters will be available online under the Events and Presentations section of the CytomX website at the time of presentation at www.CytomX.com.
Conference Call and Webcast
CytomX will host a conference call and webcast to discuss these presentations on Monday, October 22, 2018 at 2:30 p.m. CEST/ 8:30 a.m. EDT. Participants can dial 1-877-809-6037 U.S. Toll Free or 1-615-247-0221 International using the Conference ID: 1275596.
A live webcast can be accessed under the Events and Presentations Section of CytomX’s Investor Relations section at View Source Access the website 15 minutes prior to the start of the call to download and install any necessary audio software and slides. A replay of the webcast will be archived and available on CytomX’s website for 30 days following the event.
About PROCLAIM
PROCLAIM (Probody Clinical Assessment In Man) is an international umbrella program designed to evaluate CytomX Probody therapeutics. The first module is the PROCLAIM-072 clinical program, an open-label, dose-finding Phase 1/2 trial evaluating CX-072 as monotherapy and in combination with Yervoy (ipilimumab) or Zelboraf(vemurafenib) in patients with metastatic or locally advanced unresectable solid tumors or lymphomas. CytomX aims to achieve three goals as part of the PROCLAIM-072 clinical trial:
Tolerability: Demonstrate that CX-072 is well tolerated in patients, and potentially improves safety, particularly in the combination setting.
Anti-cancer activity: Demonstrate initial evidence of CX-072’s anti-cancer activity as monotherapy and in combination.
Translational program and Probody platform proof-of-concept: Explore mechanistic aspects of Probody activity in patients as observed in preclinical models.