On November 7, 2018 Immunomic Therapeutics Inc. (ITI) Scientist Amit Adhikara reported that it will present at the Society for NeuroOncology 2018 Annual Meeting in New Orleans (Press release, Immunomic Therapeutics, NOV 7, 2018, View Source [SID1234530943]). The presentation will focus on Immunomic’s recently-expanded investigational UNiversal Intracellular Targeted Expression (UNITE) platform and its application in immuno-oncology, specifically glioblastoma multiforme (GBM).
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Immunomic’s technology platform has the potential to utilize the body’s natural biochemistry to develop a broad immune response, including antibody production, cytokine release and critical immunological memory. This approach could put Immunomic’s platform technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in a Phase II clinical trial as a cancer immunotherapy.
Details of Immunomic’s poster presentation are below:
Who: Amit Adhikara, Scientist at Immunomic Therapeutics
What: Development of Cytomegalovirus (CMV) Based DNA Vaccines for GBM Using the UNITE Platform
When: Friday, November 16 at 7:30 p.m. CST
Where: Marriott Hotel, 555 Canal Street, New Orleans, LA, 70130
About UNITE
ITI’s investigational UNITE platform, or UNiversal Intracellular Targeted Expression, is thought to work by encoding the Lysosomal Associated Membrane Protein, an endogenous protein in humans. In this way, ITI’s vaccines (DNA or RNA) have the potential to utilize the body’s natural biochemistry to develop a broad immune response including antibody production, cytokine release and critical immunological memory. This approach could put UNITE technology at the crossroads of immunotherapies in a number of illnesses, including cancer, allergy and infectious diseases. UNITE is currently being employed in Phase II clinical trials as a cancer immunotherapy. ITI is also collaborating with academic centers and biotechnology companies to study the use of UNITE in cancer types of high mortality, including cases where there are limited treatment options like glioblastoma and acute myeloid leukemia. ITI believes that these early clinical studies may provide a proof of concept for UNITE therapy in cancer, and if successful, set the stage for future studies, including combinations in these tumor types and others. Preclinical data is currently being developed to explore whether LAMP nucleic acid constructs may amplify and activate the immune response in highly immunogenic tumor types and be used to create immune responses to tumor types that otherwise do not provoke an immune response.