On December 4, 2018 GlycoMimetics, Inc. (NASDAQ: GLYC) reported at the 60thAmerican Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting yesterday two posters with preclinical data presentations: on GMI-1687, the company’s highly potent E-selectin antagonist that is bioavailable via subcutaneous administration, and GMI-1757, the company’s dual-function E-selectin/galectin-3 antagonist (Press release, GlycoMimetics, DEC 4, 2018, View Source [SID1234531877]).
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"The new preclinical data presented at ASH (Free ASH Whitepaper) underscore GlycoMimetics’ commitment to pioneering advances in the field of glycobiology and to rationally designing innovative drug candidates that address areas of significant unmet medical need," said John Magnani, Ph.D., Senior Vice President and Chief Scientific Officer. "The two compounds, debuted in posters, are currently in preclinical testing. The GMI-1687 poster points to the potential for a life-cycle extension for uproleselan, which is more highly-potent and is subcutaneously bioavailable in animal models. The poster on GMI-1757, a novel galectin-3/E-selectin antagonist, suggests the compound may be able to play a role in the treatment of a variety of cancers and fibrotic conditions."
Details for the two poster presentations on GlycoMimetics’ wholly owned drug candidates follow:
Publication Number: 4678
TITLE: A Novel and Potent Inhibitor of E-Selectin, GMI-1687, Attenuates Thrombus Formation and Augments Chemotherapeutic Intervention of AML in Preclinical Models Following Subcutaneous Administration
Publication Number: 2211
TITLE: A Novel Glycomimetic Compound (GMI-1757) with Dual Functional Antagonism to E-Selectin and Galectin-3 Demonstrates Inhibition of Thrombus Formation in an Inferior Vena Cava Model