On March 26, 2019 Actinium Pharmaceuticals, Inc. (NYSE American: ATNM), reported that two oral and four poster presentations related to its Ac-225 or Actinium-225 based ARC’s or Antibody Radiation-Conjugates have been accepted for presentation at the 11th Targeted-Alpha-Therapy International Symposium (TAT) being held April 1 – 4, 2019 in Ottawa, Canada (Press release, Actinium Pharmaceuticals, MAR 26, 2019, View Source [SID1234534624]). TAT is a bi-annual global conference which brings together thought leaders in alpha-particle therapy innovation. In addition to the oral and poster presentations, Actinium management will also participate in a panel entitled "The Renaissance of Radio Pharmaceuticals – A Commercial Perspective".

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Ac-225 is a potent alpha-particle emitting isotope being utilized in Actinium’s ARC programs for targeted conditioning in the planned pivotal Actimab-MDS trial as well as therapeutic and combination trials such as its Actimab-A Venetoclax combination trials and Actimab-MRD therapeutic trial. Ac-225 is also used in Actinium’s AWE or Antibody Warhead Enabling Technology Platform to support its ongoing collaboration with Astellas Pharma, Inc. and to create next-generation ARC’s. Exemplifying the potential of next-generation ARC’s is the oral presentation highlighting Ac-225 labeled daratumumab (Darzalex, Johnson & Johnson).

Dr. Dale Ludwig, Actinium’s Chief Scientific Officer, said, "Actinium-225 is an isotope with great potential for therapeutic applications given its high energy, short pathlength and 10-day half-life. Due to its highly differentiated properties, we are increasing our research related to targeted Actinium-225 through our AWE platform to continue to drive highly differentiated programs to further expand our pipeline into areas of unmet need. We are excited to have the opportunity to highlight research spanning our clinical programs, novel next-generation ARC’s and preclinical efforts with next generation Ac-225 at this year’s TAT. As a leader in Actinium-225 based ARC’s we are thrilled to be at the forefront of these efforts and are committed to continuing to advance this exciting field."

In addition to highlighting Actinium’s clinical programs and AWE platform, Actinium will present a poster comparing the feasibility of using Ac-225 produced in a high-energy linear proton accelerator by the DOE or U.S. Department of Energy to that of traditional Ac-225 produced in a "thorium cow" or generator. The studies evaluated the feasibility of conjugating or labeling accelerator produced Ac-225 to lintuzumab, an anti-CD33 monoclonal antibody used in Actinium’s CD33 ARC program, and the impact on ARC generation. The DOE’s linear proton accelerator process is in addition to its existing generator-based processes and Actinium’s proprietary process for manufacturing Ac-225 in a cyclotron, the last of which is covered by company patents, know-how and trade secrets.

Sandesh Seth, Actinium’s Chairman and CEO, said, "We are excited to present data from our Ac-225 clinical programs and AWE platform at the preeminent conference focused on targeted alpha-particle therapies. We are committed to bringing important therapies to patients with high unmet needs and feel that Ac-225 has the potential to be an optimal warhead when applied in a targeted manner as we do. We intend to stay at the forefront of innovation with the Ac-225 isotope including ARC development, manufacturing and supply. We look forward to highlighting our capabilities and leadership position in several of these areas at TAT as evidenced by the breath and scope of our participation in several oral, poster and panel sessions."

Details of Actinium’s presentations at TAT are as follows:

Oral Presentations:

Title: Highly Effective Treatment of CD38 Positive Experimental Lymphoma with Actinium-225-Daratumuamb
Sponsored by Actinium Pharmaceuticals, Inc.
Date and Time: Tuesday, April 2, 2019 10:10 AM
Presenter: Wojciech Dawicki, PhD, University of Saskatchewan
Location: Ballroom, Fairmont Chateau Laurier

Title: Targeted Alpha-Particle Therapy for Hematologic Malignancies
Date and Time: Thursday, April 4, 2019 2:00 PM
Presenter: Joseph Jurcic, MD, Columbia University Medical Center
Location: Ballroom, Fairmont Chateau Laurier

Poster Presentations:

Title: Radiolabeling of DOTA-conjugated Lintuzumab with 225Ac: Comparison of Th-229-produced and High-Energy Proton Accelerator-produced 225Ac
Date and Time: Tuesday, April 2, 2019 5:00 – 6:30 PM
Location: Canadian Room, Fairmont Chateau Laurier
Presenter: Dale Ludwig, PhD, Actinium Pharmaceuticals, Inc.
Poster #54

Title: A Phase 2 Study of Actinium-225 (Ac-225-lintuzumab) in Older Patients with Untreated Acute Myeloid Leukemia (AML)
Date and Time: Tuesday, April 2, 2019 5:00 – 6:30 PM
Location: Canadian Room, Fairmont Chateau Laurier
Presenter: Mark Berger, MD, Actinium Pharmaceuticals, Inc.
Poster #61

Title: Dosimetric Impact of Ac-227 in Accelerator-Produced Ac-225
Date and Time: Tuesday, April 2, 2019 5:00 – 6:30 PM
Location: Canadian Room, Fairmont Chateau Laurier
Presenter: George Sgouros, PhD, Johns Hopkins University
Poster #62

Title: Impact of Target Cell Number on Target Cell and Tissue Dose for Antibody-Mediated Delivery of Alpha-Emitters
Date and Time: Tuesday, April 2, 2019 5:00 – 6:30 PM
Location: Canadian Room, Fairmont Chateau Laurier
Presenter: George Sgouros, PhD, Johns Hopkins University
Poster #63

Panel

Title: The Renaissance of Radio Pharmaceuticals – A Commercial Perspective
Date and Time: Tuesday, April 2, 2019 2:25 – 3:05 PM
Location: Ballroom, Fairmont Chateau Laurier