On May 6, 2019 PIN Pharma, a company focused on modulating the immune system and having its first indication in oncology, reported the Company will be presenting a poster at the 55th Annual meeting of ASCO (Free ASCO Whitepaper) in Chicago on June 1 between 8:00 AM – 11:00 reporting the results of the first-in-human trial evaluating the immune activation and safety of PIN-2 administered to patients with advanced solid tumors (Press release, PIN Pharma, MAY 6, 2019, View Source [SID1234535772]).

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About PIN-2

PIN-2 is a novel immunomodulatory peptide with a unique mechanism of action in that it links the innate and adaptive immune systems, resulting in an enhanced immune response. In vitro and in vivo preclinical studies have shown that PIN-2 rapidly and preferentially penetrates monocytes, modifies the mRNAs involved in the induction of innate immune activation (with an attendant link to the adaptive immune system), and promotes endogenous cytotoxic T lymphocytes infiltration at the tumor site. PIN-2 acts upstream of other immune-based treatment modalities.

Given its unique, upstream immunomodulatory activity, its extensive preclinical body of evidence, and its first-in-human study results, PIN-2 holds the potential to be a new strategy in the fight against cancer and cancer-mediated immunosuppression. Further clinical research is warranted to evaluate the full potential of PIN-2 in cancer care.