On November 8, 2019 BERG, a clinical stage biopharmaceutical company that uses artificial intelligence (AI) to discover the underlying biology of disease, reported results from a study of its investigational drug BPM31510 (ubidecarenone) characterizing its immunomodulatory properties ex vivo and in tumor bearing mice. The study, presented as a poster at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting in National Harbor, Md., demonstrates a novel immuno-supportive activity of BPM31510 associated with enhanced T-cell function and diminished T-cell exhaustion which may contribute to its anti-tumor activity and synergize with Immuno-Oncology therapies (Press release, Berg, NOV 8, 2019, View Source [SID1234550774]).
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"Compromised T-cell function has a major impact on the effective anti-cancer response and outcomes observed in I/O therapies," said Dr. Niven R. Narain, BERG Co-founder, President and Chief Executive Officer. "The ability of BPM31510 to influence specific phenotypic attributes in T-cells to improve its effectiveness in the cancer microenvironment by targeting mitochondrial function represents a novel approach to impact immune system to improve cancer outcomes."
Combination of immunotherapies is under active investigation to improve anti-cancer outcomes. Immunometabolism is recognized as an important component of the immune function repertoire, an area with high untapped potential. BPM31510 impact on mitochondrial function and metabolism represents a novel and unique mechanism through its ability to synergize anti-cancer activities of I/O therapies in preclinical models and is under active investigation at BERG.
"These data set the stage to further explore BPM31510 impact on anti-tumor immunity and how to best deploy BPM31510 as part of an immunotherapy cocktail," said Vikas P. Sukhatme MD ScD, Professor of Medicine at Emory University School of Medicine and a Scientific Advisory Board member of BERG.
Details of the presentations include:
Date: Friday, November 8, 2019
BPM31510, a Metabolic Modulating Anti-Cancer Agent, Demonstrates Immune Potentiating Properties by Promoting Cytotoxic T Cells and Reversing Indices of Exhaustion and Immunosuppression
Abstract ID: P633 (Immune-stimulants and immune modulators)
Location: Poster Hall, Prince George AB of the Gaylord National Hotel & Convention Center, National Harbor MD, USA
Time: 7:00 AM – 8:00 PM
BERG collaborates with leading institutions like MD Anderson Cancer Institute (solid tumor and pancreatic trials), Harvard/BIDMC (Project Survival) and Stanford University (GBM trial), among others, in its commitment to serve patients afflicted with cancer.