On June 22, 2020 GRAIL, Inc., a healthcare company whose mission is to detect cancer early, reported that new data for its investigational multi-cancer early detection blood test will be presented at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Virtual Annual Meeting II (Press release, Grail, JUN 22, 2020, View Source [SID1234561339]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Today, the majority of deadly cancers go undetected until they have progressed to late stages, when chances of survival are much lower. This is because most deadly cancers do not have guideline-recommended screening tests available.
GRAIL’s multi-cancer early detection technology can detect more than 50 cancers, with a very low false positive rate of less than one percent, through a single blood draw. When a cancer signal is detected, the test also identifies where the cancer is located in the body (the tissue of origin) with high accuracy.
"At GRAIL, we believe that in order to bend the curve on cancer mortality, we need to transition from screening only for individual cancers, to screening individuals for all types of cancers," said Joshua Ofman, MD, MSHS, Chief Medical Officer and External Affairs at GRAIL. "These new data demonstrate our continued commitment to scientific rigor, and further support the use of our multi-cancer early detection test in broad populations."
GRAIL’s multi-cancer early detection test is supported by evidence from its population-scale clinical study program, which is believed to be the largest ever conducted in genomic medicine.
The AACR (Free AACR Whitepaper) presentation details are included below. The slides and recordings will be available on www.grail.com at the conclusion of the meeting.
AACR Presentation Details
Abstract 2308/19
Joerg Bredno, et al. Classifier performance of a cfDNA-based multi-cancer detection test on uncommon cancer types
Session PO.PR02.02 — Clinical Prevention, Early Detection, and Interception 2: June 22, 2020: 9:00AM-6:00PM EDT
Abstract 721/15
Gregory Alexander, et al. Analytical validation of a multi-cancer early detection test with tissue localization using a cell-free DNA-based targeted methylation assay
Session PO.CL11.08 — Circulating Markers 1: June 22, 2020: 9:00AM-6:00PM EDT
Abstract 2114/1
Robert Calef, et al. HPV-driven cancers show distinct methylation signatures in cell-free DNA (cfDNA)
Session PO.BSB01.05 — Multi-omic and Multimodal Discovery: June 22, 2020: 9:00AM-6:00PM EDT
Abstract 139/2
Qinwen Liu, et al. cfDNA methylation profiling distinguishes lineage-specific hematologic malignancies
Session PO.MCB05.01— DNA Methylation: June 22, 2020: 9:00AM-6:00PM EDT
About GRAIL’s Multi-Cancer Early Detection Test
GRAIL’s multi-cancer early detection blood test can detect more than 50 cancers, across all stages, with a very low false positive rate of less than one percent, through a single blood draw. When a cancer signal is detected, the test identifies where in the body the cancer is located with high accuracy, an important step to guiding diagnostic next steps and care.