On September 15, 2020 Transcenta, a global biotherapeutics company, reported success in scaling up the continuous perfusion process to 200L and completion of GMP production of a bispecific antibody for a Phase 1 clinical study (Press release, Transcenta, SEP 15, 2020, View Source [SID1234565195]).

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"This is an important milestone for Transcenta as we continue to develop and implement a highly productive perfusion platform using in-house developed chemically defined media to our pipeline programs," said Dr. Chris Hwang, CTO of Transcenta. "Given the high volumetric productivity of our perfusion processes, typical pre-pivotal clinical demand can be met with < 200L scale single-use bioreactor (SUB) while commercial supply can be met with 500L scale SUB."

This is another breakthrough for Transcenta’s perfusion platform after achieving productivity to greater than 4 g/L per day for multiple cell lines earlier this year. Transcenta will work on developing innovative technology like Integrated Continuous Bioprocessing and improving development and manufacturing capability to help accelerate new biologics’ clinical progress, moving forward to our mission of employing cutting edge technology to deliver speed and affordable high-quality innovative biologics to patients around the world.