Bicycle Therapeutics to Present Posters at the SITC 35th Anniversary Annual Meeting

On October 14, 2020 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported that preclinical data for BT7480, a tumor-targeted immune cell agonist (TICA), and an EphA2/CD137 TICA will be presented during an e-poster session at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 35th Anniversary Annual Meeting on November 10-15, 2020 (Press release, Bicycle Therapeutics, OCT 14, 2020, View Source [SID1234568482]).

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BT7480 is a novel, fully synthetic TICA targeting Nectin-4, a well-validated tumor antigen, and agonizing CD137. EphA2/CD137 TICAs are comprised of Bicycles that target the tumor antigen EphA2, which is overexpressed in a range of solid tumor types and associated with poor outcomes, and Bicycles that agonize CD137.

Details on Bicycle’s poster presentations at SITC (Free SITC Whitepaper) are as follows:

Poster Title: BT7480, a fully synthetic tumor-targeted immune cell agonist (TICA) induces tumor localized CD137 agonism and modulation of tumor immune microenvironment
Abstract #: 706
Session Date and Time: Wednesday, November 11, 2020 – Saturday, November 14, 2020; 9:00 a.m. – 5:00 p.m. ET

Poster Title: EphA2/CD137 Bicycle tumor-targeted immune cell agonists (TICAs) induce tumor regressions, immunogenic memory, and reprogramming of the tumor immune microenvironment
Abstract #: 700
Session Date and Time: Wednesday, November 11, 2020 – Saturday, November 14, 2020; 9:00 a.m. – 5:00 p.m. ET

The posters will be available on the Publications section of bicycletherapeutics.com following presentation.