On October 22, 2020 Asana BioSciences, a clinical stage biopharmaceutical company, reported that ASN007 clinical data on safety, efficacy and pharmacokinetics in solid tumor patients will be presented at the 32nd EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) Virtual Symposium on Molecular Targets and Cancer Therapeutics (ENA 2020) to be held on October 24-25, 2020 (Press release, Asana BioSciences, OCT 22, 2020, View Source [SID1234568862]). Details of this invited presentation are as follows:
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Title: Targeting ERK with novel inhibitor ASN007
Presenter: Filip Janku, MD, PhD. Associate Professor, Investigational Cancer Therapeutics (Phase I Clinical Trials Program), The University of Texas MD Anderson Cancer Center
Session Title: New Drugs on the Horizon
Date and Time: Sunday, October 25, 2020 at 21:00 CET/4:00 PM US ET
About ASN007
ASN007 is an orally bioavailable, potent and selective inhibitor of ERK1/2 designed to potently inhibit the RAS/RAF/MEK/ERK (MAPK) signaling pathway. ASN007 shows potent preclinical activity in KRAS-driven models, irrespective of subtype mutation, and in BRAF mutant models, including RAF/MEK inhibitor-resistant melanoma. ASN007 has a long target residence time and shows activity in preclinical models using an intermittent dosing schedule. ASN007 has been evaluated in patients with advanced solid tumors, including BRAF- and KRAS-mutant cancers (NCT03415126). The maximum tolerated dose levels (MTD) and recommended Phase 2 dose (RP2D) has been determined. Clinical development of ASN007 is ongoing and aims to address the medical need across a range of cancer types defined by RAS/RAF/MEK driven mutations as monotherapy and in combinations.