On November 5, 2020 XOMA Corporation (Nasdaq: XOMA), reported recent royalty asset portfolio advancements and its third quarter 2020 financial results (Press release, Xoma, NOV 5, 2020, View Source [SID1234570155]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
"Our partners continue to make advances in their missions to bring new therapies to patients in need. Recently, two separate partners dosed the first patients in their respective Phase 2 studies – Novartis with NIS793, an anti-TGFß monoclonal antibody, in patients with metastatic pancreatic cancer, and one undisclosed partner’s Phase 2 trial in an undisclosed indication. These two events resulted in our earning a combined $25.5 million in milestones, and a portion of the $25 million Novartis milestone will be applied to reduce our Novartis debt obligation to less than $10 million," stated Jim Neal, Chief Executive Officer at XOMA. "Another three partners announced the initiation of Phase 2 studies in the third quarter – Bayer’s osocimab CONVERT study in patients with kidney failure requiring hemodialysis, Rezolute’s RZ358 study in congenital hyperinsulinism, and Incyte’s triple combination therapy study in select advanced malignancies. Additionally, the medical community received its first look at early data from two assets in our portfolio, Merck’s MK-4830 and Alligator/Janssen’s mitazalimab (anti-CD40 mAb), via presentations at medical conferences over the summer.
"We were pleased to learn Rezolute completed a sizable fundraise that attracted high-quality investors. Their successful financing resulted in the accelerated payment of $1.4 million to XOMA," Mr. Neal continued. "On the royalty interest acquisition front, we exercised our option to acquire the royalty rights associated with the enzymes being investigated as potential treatments for four lysosomal storage disorders under Bioasis’ strategic alliance with Chiesi Group. This basket of enzymes expands our portfolio beyond monoclonal antibodies and small molecules and adds another four assets to our potential milestone and royalty portfolio of 65-plus disclosed and undisclosed assets."
Financial Results
XOMA recorded total revenues of $0.6 million for the third quarter of 2020, compared with $8.9 million in the third quarter of 2019. The decrease for the three months ended September 30, 2020, as compared to the corresponding period of 2019, was primarily due to $6.0 million recognized under the Rezolute agreement and $2.5 million recognized under the Janssen license agreement in the third quarter of 2019.
Research and development expenses were $0.03 million for the third quarter of 2020, compared to $0.1 million for the third quarter of 2019. The decrease of $0.1 million for the three months ended September 30, 2020, compared to the same period of 2019, was due to a $0.1 million decrease in salary and related expenses as a result of the recategorization of employees to department codes mapped to general and administrative expenses.
General and administrative ("G&A") expenses were $3.2 million for the third quarter of 2020, compared to $5.8 million for the third quarter of 2019. The decrease of $2.6 million between the corresponding periods of 2020 and 2019 was primarily due to a $1.3 million decrease in salary and related expenses and a $0.9 million decrease in facilities costs.
In the third quarter of 2020, G&A expenses included $0.7 million in stock-based compensation, which is a non-cash expense. The Company’s net cash used in operations was $2.4 million.
In the third quarter of 2020, XOMA recorded $0.4 million in total interest expense, as compared to $0.5 million in the corresponding period of 2019, both of which reflect the Company’s outstanding loan balances with Silicon Valley Bank (SVB) and Novartis.
Net loss for the third quarter of 2020 was $1.1 million, compared to net income of $3.2 million for the third quarter of 2019.
On September 30, 2020, XOMA had cash of $45.7 million. The Company ended December 31, 2019, with cash of $56.7 million. Since September 30, 2020, XOMA has earned $25.5 million, including debt reduction, from its partners. The Company continues to believe its current cash balance will be sufficient to fund XOMA’s operations for multiple years.