On December 16, 2020, in connection with the consummation of the previously reported offering and sale by Lexicon Pharmaceuticals, Inc. (the "Company") of 20,312,500 shares of the Company’s common stock, par value $0.001 per share, in a registered direct offering to Artal International S.C.A. ("Artal"), an affiliate of Invus, L.P. ("Invus"), and certain other investors, the Company entered into a Supplement No. 3 (the "Supplement") with Invus and Invus C.V. supplementing the terms of the Company’s stockholders’ agreement ("Stockholders’ Agreement") and registration rights agreement ("Registration Rights Agreement") with Invus, each dated June 17, 2007 (as previously amended, supplemented or otherwise modified, the "Transaction Agreements") (Filing, 8-K, Lexicon Pharmaceuticals, DEC 16, 2020, View Source [SID1234573069]).

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The Supplement amends (i) the definition of "Investor" in the Stockholders’ Agreement to include Artal and its affiliates and (ii) the definition of "Holders" in the Registration Rights Agreement to include Artal and its affiliates. Artal is an affiliate of Invus, the Company’s largest stockholder.

The foregoing summary of the Supplement does not purport to be complete and is qualified in its entirety by reference to the full text of the Supplement. A copy of the Supplement is attached hereto as Exhibit 10.1 and is incorporated herein by reference.