On April 10, 2021 MacroGenics, Inc. (Nasdaq: MGNX), a biopharmaceutical company focused on developing and commercializing innovative monoclonal antibody-based therapeutics for the treatment of cancer, reported presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 10-15, 2021 (Press release, MacroGenics, APR 10, 2021, View Source [SID1234577831]).

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"This year’s AACR (Free AACR Whitepaper) presentations highlight three antibody-based technologies upon which multiple molecules are being developed at MacroGenics," said Ezio Bonvini, M.D., Senior Vice President and Chief Scientific Officer of MacroGenics. "We are presenting pre-clinical data on MGC018, our clinical-stage, investigational antibody-drug conjugate (ADC) targeting B7-H3. At clinically relevant dose levels, MGC018 demonstrated potent antitumor activity in vivo in mouse patient-derived xenograft (PDX) models of squamous cell carcinoma of the head and neck (SCCHN). MGC018 is currently being investigated in a Phase 1 dose expansion study in advanced solid tumor cancers, including metastatic castration-resistant prostate cancer (mCRPC), non-small cell lung cancer (NSCLC) and triple negative breast cancer (TNBC)."

"A second poster demonstrates that margetuximab, our Fc-engineered anti-HER2 mAb developed using our Fc Optimization platform, can upregulate checkpoint molecules on Natural Killer (NK) cells, CD8 T cells and tumor cells, potentially sensitizing them to immune checkpoint blockade. Consistent with this observation, PD-1 and LAG-3 blockade by tebotelimab, our investigational bispecific PD-1 × LAG-3 DART molecule, enhances margetuximab-mediated NK cell cytolytic activity in vitro," added Dr. Bonvini. "Finally, our third poster highlights pre-clinical data on IMGC936, an investigational ADAM9-directed ADC being developed in collaboration with ImmunoGen Inc. ADAM9 is highly expressed in a large number of solid tumors and our presentation shows that IMGC936 has activity against multiple solid tumor types in in vivo mouse PDX models. IMGC936 is currently being studied in a Phase 1 clinical trial evaluating safety and pharmacokinetics in cancer patients. Together, these results illustrate the drug development potential of all three technologies MacroGenics is deploying to identify and advance promising anti-cancer drug candidates."

Presentation details are as follows:

April 10, 2021, 8:30 AM – 11:59 PM
1555 – Enhanced HER2-dependent immune activation by margetuximab, an investigational Fc-engineered anti-HER2 mAb, supports combination with checkpoint blockade
Session PO.IM02.02 – Combination Immunotherapies

April 10, 2021, 8:30 AM – 11:59 PM
950 – Targeting B7-H3 in squamous cell carcinoma of the head and neck: Preclinical proof-of-concept with the investigational anti-B7-H3 antibody-drug conjugate, MGC018
Session PO.ET07.01 – Biological Therapeutic Agents

April 10, 2021, 8:30 AM – 11:59 PM
1841 – IMGC936, an investigational ADAM9-targeting antibody drug conjugate, is active against patient-derived ADAM9-expressing xenograft models
Session PO.IM02.10 – Therapeutic Antibodies, Including Engineered Antibodies

Posters of the above presentations may be accessed under "Events & Presentations" in the Investor Relations section of MacroGenics’ website at View Source