On May 10, 2021 NOXXON Pharma N.V. (Paris:ALNOX) (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that an independent Data Safety Monitoring Board (DSMB) has confirmed that the highest dose of NOX-A12 in combination with radiotherapy in the ongoing Phase 1/2 study in patients with brain cancer is safe and that the trial should continue as planned.

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The study investigates three dose regimens of NOX-A12 (200, 400 and 600 mg/week), each combined with external-beam radiotherapy in newly diagnosed brain cancer patients. The DSMB recommendation to proceed followed the analysis of safety data stipulated in the study protocol after all three patients in the third – and last – cohort completed at least four weeks of treatment at the highest dose.

"We are pleased that the DSMB analysis has concluded that the highest dose of NOX-A12 in this Phase 1/2 study in brain cancer patients is safe. We look forward to continuing to investigate this exciting potential treatment and continue to expect top-line data for Cohort 2 end-May and Cohort 3 in November 2021," commented Aram Mangasarian, CEO of NOXXON.