On June 10, 2021 Phosplatin Therapeutics Inc., a clinical stage pharmaceutical company focused on oncology therapeutics, reported that it has been selected to deliver a presentation on the development program of its lead candidate, PT-112, an immunogenic cell death (ICD) inducer, at 2021 BIO Digital, the premier biotech event (Press release, Phosplatin, JUN 10, 2021, View Source [SID1234583852]). BIO Digital is scheduled June 10-11 and 14-18, 2021, and presentations will be available on-demand throughout the event.
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Robert Fallon, President and Chief Executive Officer, will present the company and its lead clinical candidate, PT-112, a novel small molecule conjugate of pyrophosphate with a pleiotropic mechanism of action that promotes immunogenic cell death (ICD) in the tumor microenvironment. The presentation will be available to registered attendees beginning at 9 am ET on June 10.
"We’re looking forward to presenting PT-112 at BIO so that investors and potential partners can understand our encouraging results to date, which include drug responses in several tumor types of heavily pre-treated patients with advanced metastatic disease," said Fallon. "Data reported from three Phase 1 studies demonstrate feasibility and activity, both as a monotherapy and in combination with PD-L1 immune checkpoint inhibition. We’re currently in Phase 2 clinical trials evaluating PT-112’s optimal dosing for a planned pivotal study, as well as preliminary evidence of efficacy, alongside extensive correlative research using sophisticated liquid sampling technology platforms."
Attendees at BIO Digital will be able to view Phosplatin’s Company Presentation before live meetings in the BIO One-on-One Partnering system begin on June 14. To meet with Phosplatin at BIO Digital, information is available here.
About PT-112
PT-112 is a novel small molecule conjugate of pyrophosphate that possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents the best-in-class small molecule inducer of this immunological form of cancer cell death and is currently under Phase II development. Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone. The first in-human study of PT-112 demonstrated an attractive safety profile and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO (Free ESMO Whitepaper) 2018 Annual Congress. The combination Phase Ib dose escalation study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO (Free ESMO Whitepaper) 2020 Virtual Congress. The Phase I study in patients with relapsed or refractory multiple myeloma presented at ASH (Free ASH Whitepaper) is the third completed Phase I study of PT-112. Monotherapy phase 2 development is ongoing in mCRPC, and the PD-L1 combination study is ongoing in a dose confirmation cohort of non-small cell lung cancer (NSCLC) patients.