On June 17, 2021 Cullgen Inc., a leading biotechnology company developing small molecule therapeutics based on its proprietary uSMITE platform of targeted protein degradation technology, reported that Drs. Jian Jin and Yue Xiong, co-founders of Cullgen, have published a review of targeted protein degradation technology as well as a comprehensive summary of degraders in development for the treatment of cancer in the prestigious journal, Nature Reviews Cancer (Press release, Cullgen, JUN 17, 2021, View Source [SID1234584161]). The article reviews the history and mechanism of targeted protein degradation, the ubiquitin-proteasome system, and the key principles required for design of heterobifunctional small-molecule degraders. The publication also contains an in-depth review of the current state and challenges associated with the use of common E3 ligands. The article is entitled "Advancing targeted protein degradation for cancer therapy". The complete publication can be found on-line here: View Source

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"The use of targeted protein degradation principles by pharmaceutical companies has now become ubiquitous in drug development strategies", said Dr. Jin. "We are thrilled to see that forty years of research on the ubiquitin-proteasome system has made such a significant contribution to drug discovery", added Dr. Xiong, Cullgen’s Chief Scientific Officer. "We look forward to witnessing more targeted protein degraders entering human clinical trials in the near future".

"As pioneers in ubiquitin ligase and protein degradation field, the contributions of Drs. Jin and Xiong have positioned Cullgen as one of the leading companies in this revolution of drug discovery. Since the founding of Cullgen about three years ago, we have built an extensive therapeutic pipeline utilizing conventional and novel E3 ligands developed in house", said Ying Luo, Chairman and President of Cullgen. "Our co-founders’ visionary insights into the complicated ubiquitin-proteasome system provide Cullgen with a clear advantage in the development of the next generation of targeted therapies."