On September 13, 2021 Medivir AB (Nasdaq Stockholm: MVIR) reported that the Abstract entitled "Phase 1 study of the novel prodrug MIV-818 in patients with hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (iCCA) or liver metastases (LM)" has been released on the European Society for Medical Oncology (ESMO) (Free ESMO Whitepaper) website (View Source) (Press release, Medivir, SEP 13, 2021, View Source [SID1234587651]).
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The results from the completed phase 1b monotherapy dose escalation part of the study will be presented by
Dr Debashis Sarker, King´s College, London, as an e-poster (number 527P) at ESMO (Free ESMO Whitepaper) on Thursday September 16. Medivir will host a conference call to update on the progress and plans for the MIV-818 program at 15.00 CET on September 16.
About MIV-818
MIV-818 is a pro-drug designed to selectively treat liver cancers and to minimize side effects. It has the potential to become the first liver-targeted and orally administered drug for patients with HCC and other forms of liver cancer. MIV-818 has completed a phase 1b monotherapy study, and a combination study in HCC is now planned to be initiated during the second half of 2021.
About primary liver cancer
Primary liver cancer is the third leading cause of cancer-related deaths worldwide and hepatocellular carcinoma (HCC) is the most common cancer that arises in the liver. Although existing therapies for advanced HCC can extend the lives of patients, treatment benefits are insufficient and death rates remain high. There are 42,000 patients diagnosed with primary liver cancer per year in the US and current five-year survival is 11 percent. HCC is a heterogeneous disease with diverse etiologies, and lacks defining mutations observed in many other cancers. This has contributed to the lack of success of molecularly targeted agents in HCC. The limited overall benefit, taken together with the poor overall prognosis for patients with intermediate and advanced HCC, results in a large unmet medical need.