On October 12, 2021 Cellectis S.A. (NASDAQ: CLLS – EURONEXT GROWTH: ALCLS) (the "Company"), a gene-editing platform company with clinical-stage immuno-oncology programs using allogeneic chimeric antigen receptor (CAR)-T cells and gene therapy programs for genetic diseases, reported that pre-clinical data that support anti-tumor activity of UCARTMESO will be presented at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s 36th Annual Meeting (SITC 2021), to be held in Washington, D.C. and virtually on November 10 to 14, 2021 (Press release, Cellectis, OCT 12, 2021, View Source [SID1234591101]).
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Cellectis will present a poster on UCARTMESO, an allogeneic CAR-T cell product candidate targeting mesothelin – expressing solid tumors. Mesothelin is a tumor-associated antigen that is highly and consistently expressed in mesothelioma and pancreatic cancer and is also over-expressed in subsets of other solid tumors (ovarian cancer, non-small cell lung cancer, gastric cancer, triple-negative breast cancer). UCARTMESO also leverages its TALEN gene editing technology to resist immune suppression mediated by TGFβ.
Last May, during its Innovation Days, Cellectis announced the development of the new pre-clinical UCART product candidates targeting B-cell lymphomas and venturing for the first time into the solid tumor space.
Presentation Details:
Title: Mesothelin (MSLN) targeting allogeneic CAR-T cells engineered to overcome tumor immunosuppressive microenvironment
Poster Number: 143
Presenter: Roman Galetto, Ph.D, Director, Preclinical and Program Management
Date/Time: Friday November 12, 7:00AM – 8:30PM, Walter E. Washington Convention Center, Poster Hall (Hall E)
Full text of the abstracts will be released on the SITC (Free SITC Whitepaper) website at 7:00 a.m. ET on November 12, 2021.