On November 12, 2021 NOXXON Pharma N.V. (Euronext Growth Paris: ALNOX), a biotechnology company focused on improving cancer treatments by targeting the tumor microenvironment (TME), reported that interim data from the ongoing Phase 1/2 GLORIA trial in brain cancer will be presented by Dr. Frank Giordano in an oral presentation at the Society for Neuro-Oncology (SNO) Annual Meeting (Press release, NOXXON, NOV 12, 2021, View Source [SID1234595294]). The meeting will take place in Boston, Massachusetts, USA from November 18 to 21, 2021.
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Dr. Frank Giordano, lead investigator of the GLORIA study, commented: "For many years, I have been focused on optimizing radiation therapy of brain cancers to offer patients more effective treatments that do not come at the costs of higher toxicity. The clinical data obtained to date from the combination of NOX-A12 with radiotherapy, that I will be presenting at the SNO, show a mild toxicity profile and at the same time encouraging efficacy. I am very much looking forward to seeing the results of six months of therapy of patients in the high-dose cohort in Q1 2022. To gather further data, we have also expanded the study to evaluate additional treatment combinations of NOX-A12 and radiotherapy."
The oral presentation entitled "CXCL12 inhibition in MGMT unmethylated glioblastoma – results of an early proof-of-concept assessment in the multicentric phase I/II GLORIA trial" will present and discuss the results of the proof-of-concept study on CXCL12 inhibition during and after radiotherapy of brain cancer. Patients enrolled are all newly diagnosed with MGMT promoter unmethylated glioblastoma (GBM), that do not respond to standard of care chemotherapy (temozolomide). Advanced MRI and multiplexed immunofluorescence of treated patient samples suggest efficacy of combined radiotherapy and CXCL12 inhibition in unmethylated GBM. In addition, outcomes of patients treated with NOX-A12 and radiotherapy will be compared to a matched historical cohort of patients who received standard of care. More information about the GLORIA study (NCT04121455) can be found at ClinicalTrials.gov.
Details of the oral presentation are as follows:
Title: CXCL12 inhibition in MGMT unmethylated glioblastoma – results of an early proof-of-concept assessment in the multicentric phase I/II GLORIA trial (NCT04121455)
Abstract: download
Session Title: Abstract Session: Clinical Trials I
Session Date: Friday, November 19, 2021
Presentation Time: 05:00 p.m. EST // 11:00 p.m. CET
Presenter: Dr. Frank Giordano, Director and Chairman of the Department of Radiation Oncology at the University Hospital Bonn, Germany
Registration: To register to the event, please click here.
The NOXXON team will attend the conference in person. A copy of the presentation will be made available on the NOXXON website at the time of Dr. Giordano’s presentation.