On November 12, 2021 Alligator Bioscience AB ("Alligator" or the "Company") reported that the design and scientific rationale of OPTIMIZE-1, Alligator´s phase 2 study (NCT02829099) in 1st line metastatic pancreatic cancer in combination with mFOLFIRINOX, will be presented at the Society for Immunotherapy Cancer’s (SITC) (Free SITC Whitepaper) 36th Annual Meeting & Pre-Conference Programs virtually on November 10th – 14th, 2021 (Press release, Alligator Bioscience, NOV 12, 2021, View Source [SID1234595321]).
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"Mitazalimab, a best-in-class second generation CD40 agonist, reported positive clinical data from Phase I studies, displaying a manageable safety profile, proof-of-mechanism as well as early signs of efficacy. OPTIMIZE-1 reinforces our commitment to developing mitazalimab in combination with standard of care therapies," stated Yago Pico de Coaña, PhD., Medical Science Director at Alligator Bioscience. "Targeting CD40 with mitazalimab in pancreatic ductal adenocarcinoma (PDAC), has the potential to augment responses to chemotherapy, initiating an effective anti-tumor immune response and potentially better tumor control."
Title: OPTIMIZE-1, an open-label phase 1b/2 study assessing the safety and efficacy of mitazalimab in combination with chemotherapy in patients with metastatic pancreatic ductal adenocarcinoma
Presenter: Yago Pico de Coaña, PhD.
Virtual Meeting II: E-Posters Session: Poster
The above poster presentation will be available online at www. View Source on Saturday, November 13, 2021.