On March 8, 2022 Xencor, Inc. (NASDAQ: XNCR), a clinical-stage biopharmaceutical company developing engineered antibodies and cytokines for the treatment of cancer and autoimmune diseases, reported it will present preclinical data on two novel XmAb cytokine programs at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, being held April 8-13, 2022 at the New Orleans Ernest N. Morial Convention Center in New Orleans (Press release, Xencor, MAR 8, 2022, View Source [SID1234609667]).
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"Cytokines evolved to be highly active and short acting immune signaling molecules, which makes them difficult to repurpose for therapeutic use. We have applied our protein engineering expertise and Fc technologies to create a broad set of XmAb cytokine drug candidates, designed to be long acting and drug-like," said John Desjarlais, Ph.D., senior vice president and chief scientific officer at Xencor. "We look forward to sharing our first preclinical data from two additional wholly owned cytokine programs, a decoy-resistant and potency-reduced IL18-Fc fusion protein, and a LAG-3 targeted IL15/IL15α-Fc fusion protein, which is biased toward binding and activating checkpoint-upregulated lymphocytes that are more likely to be tumor-reactive."
Poster Presentation Details
Abstract 2080, "LAG3-targeted IL15/IL15Rα-Fc (LAG3 x IL15) fusion proteins for preferential TIL expansion"
Session: Immunomodulatory Agents and Interventions 1
Date and Time: Monday, April 11, 2022, 1:30 – 5:00 p.m. CDT
Location: Exhibit Halls D-H, Section 38, Board 18
Abstract 3515, "Engineered IL18 heterodimeric Fc-fusions featuring improved stability, reduced potency, and insensitivity to IL18BP"
Session: Immunomodulatory Agents and Interventions 2
Date and Time: Tuesday, April 12, 2022, 1:30 – 5:00 p.m. CDT
Location: Exhibit Halls D-H, Section 37, Board 17
Abstracts are now available on AACR (Free AACR Whitepaper)’s website located at www.aacr.org. E-posters will be available to registrants of the AACR (Free AACR Whitepaper) Annual Meeting at 1:00 p.m. EDT on Friday, April 8. Posters will be archived under "Events & Presentations" in the Investors section of the Company’s website located at www.xencor.com.