On March 8, 2022 Kinnate Biopharma Inc. (Nasdaq: KNTE) ("Kinnate"), a biopharmaceutical company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers, reported abstracts highlighting the company’s lead RAF kinase inhibitor program, KIN-2787, have been accepted for presentation at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2022, to be held April 8-13, in New Orleans, Louisiana (Press release, Kinnate Biopharma, MAR 8, 2022, View Source [SID1234609744]).
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Abstracts accepted for poster presentation include:
Occurrence of BRAF class II and III alterations is common across solid tumors and is associated with inferior clinical outcomes in NSCLC and melanoma (PAN# 4122). The poster will be presented by Paul Severson, Ph.D., Senior Director of Translational Medicine & Bioinformatics at Kinnate.
Design and rationale of a first in human (FIH) Phase 1/1b study evaluating KIN-2787, a potent and highly selective pan-RAF inhibitor, in adult patients with BRAF- and NRAS-mutation positive solid tumors (PAN# CT248). The poster will be presented by Meredith McKean, M.D., M.P.H., Director, Melanoma and Skin Cancer Research Program, Sarah Cannon Research Institute at Tennessee Oncology.
Antitumor activity of KIN-2787, a next-generation pan-RAF inhibitor, in preclinical models of human RAF/RAS mutant melanoma (PAN# 2674). The poster will be presented by Nichol Miller, Ph.D., Senior Director of Translational & Discovery Biology at Kinnate.
"We are honored that these abstracts focused on our RAF program were selected for presentation at this year’s AACR (Free AACR Whitepaper) annual meeting," said Richard Williams, MBBS, Ph.D., Chief Medical Officer at Kinnate. "The majority of oncogenic BRAF alterations are Class II or III alterations that function as dimers to drive cancer cell growth. In certain cancers, outcomes for patients with BRAF Class II or III alterations are inferior when treated with available therapies. In preclinical studies, KIN-2787 has demonstrated its potential as a promising next-generation RAF inhibitor with unique properties that have demonstrated potent activity against a variety of oncogenic BRAF-driven cancers, including those where Class II and III alterations are present."
KIN-2787, is an orally available small molecule pan-RAF inhibitor being developed for the treatment of patients with lung cancer, melanoma, and other solid tumors. KIN-2787 has been designed to target both monomeric and dimeric forms of the mutant BRAF kinase and minimize paradoxical activation, a liability often observed with other RAF inhibitors that can adversely impact tolerability and require addition of a MEK inhibitor to suppress pathway activation. Unlike currently available treatments that target only Class I BRAF kinase alterations, KIN-2787 targets Class II and Class III BRAF alterations, where it has the potential to be a first-line targeted therapy, in addition to covering Class I BRAF alterations. The ongoing KN-8701 clinical trial (NCT# 04913285) of KIN-2787 is actively enrolling patients across multiple centers in the United States.
Additional information about AACR (Free AACR Whitepaper) 2022 is available at: www.aacr.org/meeting/aacr-annual-meeting-2022.