On July 19, 2022 Antengene Corporation Limited ("Antengene" SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class therapeutics in hematology and oncology, reported that it has entered into a pre-clinical research collaboration with Celularity Inc. (NASDAQ: CELU) (Celularity), a clinical-stage biotechnology company developing placental-derived allogeneic cell therapies (Press release, Antengene, JUL 19, 2022, View Source [SID1234616754]). Antengene and Celularity will evaluate the potential therapeutic synergy combining Antengene’s bispecific antibody with Celularity’s cryopreserved human placental hematopoietic stem cell-derived natural killer (NK) cell therapy platform.
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
Dr. Jay Mei, Antengene’s Founder, Chairman and CEO said, "Evaluating new technologies that may have the potential to improve cancer care, either as monotherapy or in synergistic combination with programs, is essential to Antengene’s mission. After a careful and comprehensive evaluation, Antengene is very pleased to initiate its first research collaboration in the important field of cellular medicine with Celularity."
Dr. Mei continued, "Celularity’s proprietary, novel, allogenic, cryopreserved, off-the-shelf placental-derived cellular medicine platform is very exciting to Antengene. We look forward to collaborating with the company to explore the potential synergies from the combination of Antengene’s bispecific antibody, and Celularity’s investigational NK cell therapy programs, together or in combination with other agents such as antibodies that target tumor associated antigens (TAA). We are hopeful that this collaboration will yield potential new combination therapies that will improve the treatment of patients with hematological and solid tumor cancers."
Dr. Bo Shan, Antengene’s Chief Scientific Officer said, "We are pleased to partner with Celularity’s NK cell platform. The rationale for our collaboration is based on two hypotheses, formed from a foundation of preclinical and clinical research. First, that our bispecific antibody, potentially activating NK cells upon immune checkpoint inhibitors (ICI) crosslinking in the tumor microenvironment (TME), can synergize with TAA antibodies to enhance the anti-tumor response. Second, that our bispecific antibody may enhance the proliferation of NK cells and increase their persistence in TME."
Robert J. Hariri, M.D., Ph.D., founder, Chairperson and Chief Executive Officer of Celularity, added, "We are excited to enter into this research collaboration with Antengene to forge new therapeutic strategies for both solid tumors and hematological malignancies using our placental-derived cell therapy platform. There is an immense potential for combining two novel approaches to enhance tumor targeting while also enhancing allogeneic NK cell activation and activity within the tumor microenvironment. This strategy may identify novel therapeutic options targeting a wide range of cancers."