On October 13, 2022 Palleon Pharmaceuticals, a clinical-stage company pioneering glyco-immunology drug development to treat cancer and inflammatory diseases, reported that the U.S. Patent and Trademark Office has issued Patent No.11,459,398 titled, "Conjugates for Targeted Cell Surface Editing (Press release, Palleon Pharmaceuticals, OCT 13, 2022, View Source [SID1234622000])." The patent broadens Palleon’s intellectual property position and bolsters coverage for the company’s proprietary EAGLE platform, which is based on engineered human sialidase enzymes that restore antitumor immunity by degrading immunosuppressive sialoglycans on tumors and across immune cell types.
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The patented technology is part of an exclusive license Palleon has with Stanford University and originated in the laboratory of Carolyn Bertozzi, an inventor on the patent, and a scientific co-founder of Palleon Pharmaceuticals. Dr. Bertozzi was recently awarded the 2022 Nobel Prize for Chemistry for the invention of bioorthogonal chemistry, a technology which enabled the foundational science for Palleon’s platform.
"It is thrilling to see Palleon’s pioneering EAGLE platform reach this important milestone," said Dr. Bertozzi. "Therapeutic removal of sialic acid from cells in the tumor microenvironment, as this patent describes, has shown promising potential in generating an immune antitumor response in pre-clinical studies. This glyco-immunology approach could deliver meaningful benefits for patients who don’t respond to today’s immuno-oncology treatments."
The EAGLE platform enables the development of first-in-class therapies that strip sialic acids from both immune cells and cancer cells, restoring innate and adaptive antitumor immunity. This patent covers the use in cancer of tumor-targeted antibodies conjugated to sialidase, an enzyme that cleaves sialic acid.
"This patent provides important additional intellectual property coverage for an approach that, we believe, is key to expanding the promise of immunotherapy to millions of patients, especially to those patients with immune suppression who do not respond to currently approved immunotherapy agents," said Jim Broderick, M.D., Chief Executive Officer and founder of Palleon. "With this patent solidified, we are in a strong position to continue development of an entirely new class of investigational therapies within our rich, clinical-stage pipeline."