On October 25, 2022 Spectrum Solutions, LLC reported David T.W. Wong, D.M.D., D.M.SC. of the UCLA School of Dentistry will present at the American Society of Human Genetics (ASHG) Annual Meeting 2022 on Friday, Oct. 28 at 1:00 p.m. in the CoLab Theater (Press release, Spectrum Solutions, OCT 25, 2022, View Source [SID1234622360]). This presentation will highlight the new era of saliva as a non-invasive biospecimen for CLIA-validated liquid biopsies in non-small cell lung cancer. Working from bench to bedside, the clinical utility of salivary liquid biopsies provides opportunities for both ongoing surveillance and continued monitoring following treatment.
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Previous research by UCLA researchers demonstrated detection of actionable EGFR mutations in non-small cell lung cancer (NSCLC) patients using saliva delivering a 96% and 100% sensitivity/concordance with serum. Published in The BIO Journal, Dr. Wong’s research demonstrates the ability to detect circulating tumor DNA (ctDNA) within saliva using the Electric Field–Induced Release and Measurement (EFRIM) electrostatic platform and goes a step further highlighting the superior ability and benefits of stabilized and preserved saliva using Spectrum’s SDNA-1000 saliva collection kit compared to raw saliva. Study findings illustrate and credit Spectrum’s patented stability and preservation technology for dramatically increasing sensitivity and delivering a significant 14-fold boost in signal detection for all three EGFR mutations (p<0.0001) associated with NSCLC. Additional benefits of Spectrum’s saliva collection system included improving assay reproducibility and decreasing sample variability among study participants.
Dr. Wong is a Distinguished Professor in the Division of Oral and Systemic Health Sciences and Director of the UCLA Center for Oral/Head and Neck Research and an active scientist in oral cancer and saliva diagnostics research. He has authored over 315 peer-reviewed scientific publications and is a fellow of the American Association for the Advancement of Sciences (AAAS), a past member of the ADA Council of Scientific Affairs, past president of American Association of Dental Research (AADR), chair of the NCI Liquid Biopsy Consortium, chair of the NIH Cancer Biomarker Study Section, and a member of the scientific advisory board for Spectrum Solutions.
In addition, Spectrum will be introducing their new saliva-based multi-omic collection platform with the first preservation buffer purpose-built to stabilize and preserve both salivary proteins and genomic material post-collection for multiple days at room temperature. For more information on this or Dr. Wong’s presentation stop by booth number 2123.