On October 26, 2022 Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, reported that it will be presenting two preclinical posters at the EORTC-NCI-AACR (Free EORTC-NCI-AACR Whitepaper) ("ENA") annual meeting to be held October 26-28, 2022 (Press release, Cogent Biosciences, OCT 26, 2022, View Source [SID1234622402]). Presentations and posters are available to registered attendees for on-demand viewing at View Source and will also be posted to the "Posters and Publications" page of Cogent’s website.
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The first poster discussion will provide an update on Cogent’s next-generation fibroblast growth factor receptor 2 (FGFR2) program, which retains potency across all primary, gatekeeper and molecular brake resistance mutations. The poster includes an overview of ongoing optimization of the Cogent lead series, pharmacokinetic and pharmacodynamic assessment of an FGFR1-sparing novel molecule, as well as robust efficacy in model of FGFR2 clinical resistance (N549K).
The second poster will provide initial preclinical results from Cogent’s novel ErbB2 mutant selective program. Currently available oral ErbB2 inhibitors struggle to provide broad mutant coverage while sparing EGFR activity. Cogent’s exemplar molecule demonstrates robust cellular inhibition of all key resistance and primary driver mutations, while sparing wild type EGFR target engagement. In addition, the advanced compound demonstrates dose ascendable pharmacokinetics, robust tumor phospho-ErbB2 suppression (L755S), and superior tumor growth inhibition when compared to tucatinib.
"The preclinical data presented today highlight an update on two of the first programs undertaken by the Cogent Research Team," said Andrew Robbins, Cogent’s President and Chief Executive Officer. "In the case of both FGFR2 and ErbB2 driven cancers, we believe there remains significant unmet need for therapeutic options with better product profiles than available therapies. Starting with bezuclastinib and continuing with these two targets, our singular focus is to deliver best-in-class medicines for patients fighting genetically driven diseases."