On November 3, 2022 GlycoMimetics, Inc. (Nasdaq: GLYC), a late clinical-stage biotechnology company discovering and developing glycobiology-based therapies for cancers and inflammatory diseases, reported that data from two investigator-sponsored trials studying uproleselan in patients with acute myeloid leukemia (AML) have been accepted for poster presentation at the 64th American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting (Press release, GlycoMimetics, NOV 3, 2022, View Source [SID1234622907]).
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"We are excited to share initial results from these two investigator-sponsored trials of uproleselan regarding safety and preliminary efficacy in frontline unfit and treated secondary AML populations not previously studied with this novel investigational agent," said Edwin Rock, M.D., Ph.D., Chief Medical Officer. "These presentations provide the first uproleselan clinical data generated outside of company-sponsored studies. We thank these investigators and patients for their efforts and consent, respectively, to help us learn how adding uproleselan to existing therapies may benefit people with heterogeneous forms of AML."
Details on GlycoMimetics posters at the ASH (Free ASH Whitepaper) Meeting are as follows (all times CT):
Publication Number: 1448
Title: Uproleselan Added to Cladribine Plus Low Dose Cytarabine (LDAC) in Patients with Treated Secondary Acute Myeloid Leukemia (TS-AML)
Authors: Emmanuel Almanza-Huante, Hagop Kantarjian, Kelly Chien, Courtney Dinardo, Nicholas Short, Abhishek Maiti, Guillermo Montalban-Bravo, Naval Daver, Jitesh Kawedia, Kayleigh Bowie, Sherry Pierce, Farhad Ravandi, Marina Konopleva, Guillermo Garcia-Manero, Tapan M. Kadia
Session Name: 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster I
Session Date/ Presentation Time: Saturday, December 10, 2022, 5:30 PM – 7:30 PM
Location: Ernest N. Morial Convention Center, Hall D
Publication Number: 2764
Title: A Phase I Study of Uproleselan Combined with Azacitidine and Venetoclax for the Treatment of Older or Unfit Patients with Treatment Naïve Acute Myeloid Leukemia
Authors: Brian A Jonas, Jeanna L Welborn, Naseem S Esteghamat, Rasmus T Hoeg, Aaron S Rosenberg, Laura Molnar, Ashley Linh Dang-Chu, Susan L Stewart, Joseph M Tuscano
Session Name: 616. Acute Myeloid Leukemias: Investigational Therapies, Excluding Transplantation and Cellular Immunotherapies: Poster II
Session Date/Presentation Time: Sunday, December 11, 2022, 6:00 PM – 8:00 PM
Location: Ernest N. Morial Convention Center, Hall D
About Uproleselan
Discovered and developed by GlycoMimetics, uproleselan is an investigational, first-in-class, targeted inhibitor of E-selectin. Uproleselan (yoo’ pro le’se lan), currently in a comprehensive Phase 3 development program in AML, has received Breakthrough Therapy Designation from the U.S. Food and Drug Administration and from the Chinese National Medical Products Administration for the treatment of adult AML patients with relapsed or refractory disease. Uproleselan is designed to block E-selectin (an adhesion molecule on cells in the bone marrow) from binding with blood cancer cells as a targeted approach to disrupting well-established mechanisms of leukemic cell resistance within the bone marrow microenvironment.