On January 17, 2023 Xenetic Biosciences, Inc. (NASDAQ:XBIO) ("Xenetic" or the "Company"), a biopharmaceutical company focused on advancing innovative immune-oncology technologies addressing hard to treat oncology indications, reported that the Canadian Intellectual Property Office (CIPO) has issued a notice of allowance for Patent Application No. 3,001,543 titled, "Method to Improve Safety and Efficacy of Anti-Cancer Therapy (Press release, Xenetic Biosciences, JAN 17, 2023, https://ir.xeneticbio.com/news/detail/132/xenetic-biosciences-inc-announces-notice-of-allowance-for-canadian-patent-covering-use-of-dnase-enzyme-for-preventing-or-ameliorating-toxicity-associated-with-chemotherapy [SID1234626273])." A patent from the recently allowed application is expected to be issued in the coming months.
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"We continue to be excited about the potential of the DNase platform technology and are committed to advancing its development as a top priority. As we continue to execute on our progress towards the clinic, strengthening the intellectual property portfolio around DNase is a focus for us. We are pleased to add this Canadian patent to our existing worldwide IP estate, which includes the U.S. as well as the other patent applications we have filed around the world," commented Jeffrey Eisenberg, Chief Executive Officer of Xenetic Biosciences.
The allowed patent covers claims including use of a therapeutically effective amount of a DNase enzyme for preventing or ameliorating a toxicity associated with a cytostatic and/or cytotoxic chemotherapy in a subject suffering from a cancer and received or deemed to receive said chemotherapy, wherein said amount of the DNase enzyme is effective to prevent or ameliorate at least one side effect of said chemotherapy.
The Company’s interventional DNase based oncology platform is aimed at improving outcomes of existing treatments, including immunotherapies. The Company’s exclusive license to CLS Therapeutics’ intellectual property for uses of DNases in cancer include systemic co-administration of DNases along with standard therapies, including chemotherapy, radiation and checkpoint inhibitors, or along with conventional chimeric antigen receptor (CAR) T therapies. Xenetic is focused on advancing its systemic DNase program into the clinic as an adjunctive therapy for pancreatic carcinoma and other locally advanced or metastatic solid tumors.