On January 23, 2023 TME Pharma N.V. (Euronext Growth Paris: ALTME) (Paris:ALTME), a biotechnology company focused on developing novel therapies for treatment of cancer by targeting the tumor microenvironment (TME), reported a clinical update on survival of first-line glioblastoma patients in the GLORIA expansion arm evaluating NOX-A12, the CXCL12 inhibitor, in combination with standard of care radiotherapy and anti-VEGF, bevacizumab (Press release, TME Pharma, JAN 23, 2023, View Source [SID1234626476]).

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With a median follow-up to date of 10 months in this arm of the trial median overall survival (mOS) has not yet been reached, and five of six patients (83%) remain alive. The 10-month timepoint is an important landmark for assessment since this is the expected survival for patients with MGMT unmethylated tumors and incomplete resection1.

"The data presented in November 2022 at the SNO conference demonstrated the ability of NOX-A12 in combination with radiotherapy and bevacizumab to durably shrink brain tumors in glioblastoma patients with 100% radiographic response and an 83% rate of mRANO response, which is twice as high as the mRANO response rate reported from comparable studies with bevacizumab and standard of care2," said Aram Mangasarian, CEO of TME Pharma. "We are pleased to see the data continuing to support our approach with each update, and we are keen to understand the extent of survival benefit that these patients will obtain. We will continue to provide clinical updates as the data mature."