On March 9, 2023 InnoCare Pharma (HKEX: 09969; SSE: 688428), a leading biopharmaceutical company focusing on the treatment of cancer and autoimmune diseases, reported that the first subject has been dosed in clinical trial of the Company’s B-cell lymphoma-2 (BCL2) inhibitor ICP-248 in China (Press release, InnoCare Pharma, MAR 9, 2023, View Source [SID1234628484]).

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ICP-248 is a novel, orally bioavailable BCL2 selective inhibitor, which aims to treat non- Hodgkin’s lymphoma (NHL), acute lymphoblastic leukemia (ALL) and other malignant hematological tumors as a monotherapy or in combination with BTK inhibitors and other drugs.

BCL2 is an important regulatory protein of apoptosis pathway, and its abnormal expression is related to the development of various hematologic malignancies. ICP-248 has an anti-tumor effect by selectively inhibiting BCL2 and restoring the mechanism of programmed cell death.

Dr. Jasmine Cui, the Co-founder, Chairwoman and CEO of InnoCare said, "ICP-248, as our important asset in the field of hematology, has an anti-tumor effect in the treatment of various hematologic malignancies, and can be combined with our other hematology products for synergistic effects. We have developed innovative drugs that cover a variety of important hema-oncology targets, including BTK inhibitor orelabrutinib, CD19 monoclonal antibody tafasitamab, novel targeted protein degrader ICP-490 and CD20xCD3 bispecific antibody ICP-B02. We hope to bring new treatment options for more patients with hematologic tumors."