On March 14, 2023 Asher Biotherapeutics, a biotechnology company developing precisely-targeted immunotherapies for cancer, autoimmune, and infectious diseases, reported that the company will present two poster presentations at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023, being held in Orlando, Florida, April 14-19, 2023 (Press release, Asher Biotherapeutics, MAR 14, 2023, View Source [SID1234628731]).
Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:
Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing
Schedule Your 30 min Free Demo!
A poster highlighting Asher Bio’s lead immunotherapy candidate, AB248, a CD8+ T cell-selective IL-2, will be featured as a clinical trial in progress for the ongoing Phase 1a/b study of AB248 alone and in combination with pembrolizumab in patients with advanced solid tumors who failed prior standard of care treatments. (NCT05653882).
Asher Bio will also present new preclinical data for CAR-T-specific IL-2 and IL-21 therapies demonstrating highly selective delivery of cytokine support to CAR-T cells and enhanced anti-tumor activity via distinct mechanisms. Asher Bio has engineered cis-targeted cytokine fusion molecules that specifically activate only CAR-T cells by delivering either IL-2 or IL-21, while exhibiting minimal activity on bystander cells, to offer the potential for greater activity and durability of CAR-T cell therapy.
Details of the poster presentations are as follows:
Title: An open-label, phase 1a/b study of AB248, a CD8+ selective IL-2 mutein fusion protein, alone or in combination with pembrolizumab in patients with advanced solid tumors
Authors: Elizabeth I. Buchbinder, M.D., David R. Spigel, M.D., Constantine Albany, M.D., Michael Chisamore, Ph.D., Kelly D. Moynihan, Ph.D., Xiaohan Liu, Pharm. D., Christopher DelNagro Ph.D., Matt Axt, Andrea Pirzkall, M.D.
Session Title: Phase I and First-in-Human Clinical Trials in Progress
Session Date & Time: Tuesday, April 18, 2023, 1:30 – 5:00 p.m. ET
Poster Section: 46
Poster Board Number: 13
Abstract Number: CT250
Title: Engineered cell surface tag-targeted IL-2 and IL-21 selectively and safely enhance CAR-T anti-tumor activity via different mechanisms
Authors: Nathan D. Mathewson, Ph.D., Wei Chen, Ph.D., Paul Bessette, Ph.D., Sara Sleiman, M.D., Meghana Sukthankar, Kelly D. Moynihan, Ph.D., Chris Kimberlin, Ph.D., Terrence Park, Audrey Hollingsworth; Saar Gill, M.D., Ph.D., Andy Yeung, Ph.D., Ivana Djuretic, Ph.D.
Session Title: Immunomodulatory Agents and Interventions 2
Session Date & Time: Monday, April 17, 2023, 9:00 a.m. – 12:30 p.m. ET
Poster Section: 24
Poster Board Number: 19
Abstract Number: 1847
The abstracts are now available on the AACR (Free AACR Whitepaper) conference website.