On March 15, 2023 Gritstone bio, Inc. (Nasdaq: GRTS), a clinical-stage biotechnology company working to develop the world’s most potent vaccines, reported multiple presentations at the 2023 American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting, taking place April 14-19, 2023 in Orlando, Florida (Press release, Gritstone Bio, MAR 15, 2023, View Source [SID1234628781]). The poster presentations will address the company’s proprietary neoantigen prediction capabilities (EDGE) and "off-the-shelf" neoantigen vaccine program, SLATE. The minisymposium will review results from the Phase 1/2 study of GRANITE, the company’s fully-individualized neoantigen vaccine program which is now in a randomized Phase 2/3 study for first-line microsatellite-stable colorectal cancer (MSS-CRC).

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Abstracts associated with these presentations are now available on the conference website.

Presentation details:

Abstract 5364 (Poster Presentation): Language modeling of peptide-HLA interactions achieves state-of-the-art performance on prediction of peptide presentation by HLA Class II
Date/Time: Tuesday Apr 18, 2023, 1:30 PM – 5:00 PM ET
Session: Artificial Intelligence and Machine/Deep Learning 1
Presenter: Ankur Dhanik, PhD
Location: Poster Section 31, Poster Board 13, Orange County Convention Center

Abstract 1126 (Minisymposium): Disease monitoring with comprehensive genomics provides evidence of mechanism of action and immune evasion in patients receiving an individualized neoantigen cancer vaccine
Date/Time: Sunday Apr 16, 2023, 3:37 PM – 3:52 PM ET
Session: Immunotherapy
Presenter: Matthew Davis, PhD
Location: Room W414, Orange County Convention Center

Abstract 2267 (Poster Presentation): HLA-DR-restricted CD4 T cell responses to KRAS G12C in healthy donors linked to bacterial mimotope: lessons for KRAS neoantigen vaccines in cancer patients
Date/Time: Monday Apr 17, 2023, 9:00 AM – 12:30 PM ET
Session: Immune Response to Therapies
Presenter: Christine Palmer, PhD
Location: Poster Section 43, Poster Board 14, Orange County Convention Center